Now showing items 1-10 of 710
Mapping the neurosteroid binding sites on glycine receptors
(Pergamon-Elsevier Science Ltd, 2019-09)
Glycine is a major inhibitory neurotransmitter in the CNS, where it modulates both sensory and motor transduction throughout its binding to glycine receptors (GlyRs), pentameric chloride channels that share structural and ...
The Effect of Endogenous Modulator Endobain E on NMDA Receptor Is Interfered by Zn 2+ but Is Independent of Modulation by Spermidine
(Springer/Plenum Publishers, 2004-04)
A brain endogenous factor, termed endobain E, allosterically decreases [ 3H]dizocilpine binding to NMDA receptor. Such effect depends on receptor activation by the coagonists glutamate and glycine and is interfered by ...
Allosterically linked noncompetitive antagonist binding sites in the resting nicotinic acetylcholine receptor ion channel
(Elsevier Science Inc, 2002-07-01)
Previous studies have established the presence of overlapping binding sites for the noncompetitive antagonists (NCAs) amobarbital, tetracaine, and 3-trifluoromethyl-3-(m-[ 125 I]iodophenyl) diazirine ([ 125 I]TID) within ...
Reconstitution of the steroid receptor heterocomplex
(Humana Press, 2019-03)
Steroid receptors are members of a subfamily of the nuclear receptor superfamily. They play a dual role of steroid hormone receptors and transcription factors. Actually, these receptors are steroid-activated transcription ...
Structure and dynamics of neurosteroid binding to the α1β2γ2 GABAA receptor
(Pergamon-Elsevier Science Ltd, 2018-09-01)
Neurosteroids are the principal endogenous modulators of the γ-Aminobutyric acid receptors (GABAARs), pentameric membrane-bound proteins that can be assembled from at least 19 subunits. In the most abundant GABAAR arrangement ...
Stoichiometry for activation of neuronal alpha7 nicotinic receptors.
(National Academy Of Sciences, 2013-11)
Neuronal 7 nicotinic receptors elicit rapid cation influx in response to acetylcholine (ACh) or its hydrolysis product choline. They contribute to cognition, synaptic plasticity, and neuroprotection, and have been implicated ...
Stoichiometry for activation of neuronal alpha7 nicotinic receptors
(National Academy of Sciences, 2013-12)
Neuronal α7 nicotinic receptors elicit rapid cation influx in response to acetylcholine (ACh) or its hydrolysis product choline. They contribute to cognition, synaptic plasticity, and neuroprotection and have been implicated ...
Number and Locations of Agonist Binding Sites Required to Activate Homomeric Cys-Loop Receptors
(Society for Neuroscience, 2009)
Characterization of the dizocilpine binding site on the nicotinic acetylcholine receptor
(American Society for Pharmacology and Experimental Therapeutics, 2001-05)
Although the dissociative anesthetic dizocilpine [(+)-MK-801] inhibits nicotinic acetylcholine receptor (AChR) function in a noncompetitive manner, the location of the dizocilpine binding site(s) has yet to be clearly ...
Ligand binding to CNS muscarinic receptor is transiently modified by convulsant 3-mercaptopropionic acid administration
(Springer/Plenum Publishers, 2000-06)
The administration of convulsant drugs has proven a powerful tool to study experimental epilepsy. We have already reported that the administration of convulsant 3-mercaptopropionic acid (mp) at 150 mg/kg enhances binding ...