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Autoradiographic localization of benzomorphan binding sites in rat brain
(1985)
The benzomorphan subpopulation of opiate binding sites was labeled by [3H]diprenorphine in the presence of unlabeled ligands selected to quench μ and δ opiate binding sites. The distribution of benzomorphan binding sites ...
Presence of angiotensin II and expression of angiotensin II type-2 receptor in human fallopian tube
(1998)
Objective: To determine the presence of angiotensin II and angiotensin II type-2 receptor subtype messenger RNA (mRNA) in human fallopian tube. Design: Frozen fallopian tubes were used for all studies. Setting: Procedures ...
Modulation of androgen receptor protein by culture conditions of human skin fibroblasts
(2002)
Cultures of skin fibroblasts show variation of androgen binding with culture conditions; binding variations are usually avoided by using confluent cultures. In this work, we analysed the effect of cell density and mitogenic ...
N-SUBSTITUTION AND a,-ADRENERGIC RECEPTOR AFFlNITV OJi'LAUDANOSINE ANALOGUES
(Sociedad Chilena de Química, 2006)
Benzyltetrahydroisoquinoline (BTHIQ) molecules are able to adopt widely differing conformations that depend on the presence or absence of N-substituents.
To assess the possible role of BTHIQ conformation on the affinity ...
Demonstration of specific high affinity receptors for aldosterone in cytosol of rat colon
(1986)
Since both aldosterone and glucocorticoids increase cation transport in rat distal colon, and a specific glucocorticoid high affinity cytosolic receptor has been indentified in this tissue, it was possible that the action ...
Molecular modeling of salsolinol, a full Gi protein agonist of the μ-opioid receptor, within the receptor binding site
(Blackwell Publishing Ltd, 2019)
(R/S)-Salsolinol is a full agonist of the μ-opioid receptor (μOR) Gi protein pathway via its (S)-enantiomer and is functionally selective as it does not promote β-arrestin recruitment. Compared to (S)-salsolinol, the ...
Electronic Structure and Serotonin Receptor Binding Affinity of 7-Substituted Tryptamines QSAR of 7-Substituted Tryptamines
(QSAR World, 1986)
A QSAR study was carried out seeking a relationship
between the receptor binding affinities and the molecularelectronic
structures of a group of 7-substituted tryptamines.
Tbe results suggest that these molecules interact ...
Quantum Chemical Approach to the Relationship Between Molecular Structure and Serotonin Receptor Binding Affinity
(American Pharmaceutical Association, 1983-09-13)
We have analyzed the dependence of the serotonin receptor
binding affinity on the atomic net charges, superdelocalizabilities, mass, and
moment of inertia in a group of indole derivatives. The approaches employed
are a ...
Design, synthesis, biological evaluation and binding mode modeling of benzimidazole derivatives targeting the cannabinoid receptor type 1
(Wiley-VCH Verlag, 2015)
© 2015 Wiley-VCH Verlag GmbH & Co. KGaA. A series of N-acyl-2,5-dimethoxyphenyl-1H-benzimidazoles were designed based on a CoMFA model for cannabinoid receptor type 1 (CB1) ligands. Compounds were synthesized and radioligand ...
In vivo effects of 3-iodocytisine: Pharmacological and genetic analysis of hypothermia and evaluation of chronic treatment on nicotinic binding sites
(Elsevier Ltd., 2009-05-19)
Several cytisine derivatives have been developed in the search for more selective drugs at nicotinic
acetylcholine receptors (nAChR). Binding experiments in transfected cell lines showed that the iodination
of cytisine ...