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Mechanisms of GABAA and GABAB Receptor Gene Regulation and Cell Surface Expression
(Humana Press, 2007)
The γ-aminobutyric acid (GABA) neurotransmitter acting through ionotropic and metabotropic receptor classes exerts the major inhibitory control in the central nervous system. Therapeutic agents targeting GABA receptors ...
Regulation of GABAA receptors by prolonged exposure to endogenous and exogenous ligands
(Pergamon-Elsevier Science Ltd, 2018-09)
GABAA receptors mediate most of the fast inhibitory transmissions in the central nervous system. These receptors are pentameric complexes that exhibit high structural and pharmacological heterogeneity, as they can be ...
Insulin-like growth factor-1 receptor regulation in activated human T lymphocytes
(Karger, 2003-12)
Objective: To investigate the kinetics of insulin-like growth factor-1 receptor (IGF-1R) expression in PHA-stimulated T lymphocytes. Methods: IGF-1R protein and mRNA were detected by flow cytometry and RT-PCR respectively, ...
Molecular mechanisms underlying progesterone receptor action in breast cancer: Insights into cell proliferation and stem cell regulation
(Elsevier Science Inc, 2019-12)
The ovarian steroid hormone progesterone and its nuclear receptor, the Progesterone Receptor (PR), play an essential role in the regulation of cell proliferation and differentiation in the mammary gland. In addition, ...
The glucocorticoid receptor interferes with progesterone receptor-dependent genomic regulation in breast cancer cells
(Oxford University Press, 2019-10)
The glucocorticoid and progesterone receptors (GR and PR) are closely related members of the steroid receptor family. Despite sharing similar structural and functional characteristics; the cognate hormones display very ...
Arginine-Vasopressin regulates intracellular pH via V1 and V2 receptors in renal collecting duct cells
(Karger, 2007-12)
Arginine-vasopressin (AVP) has been proposed to be involved in the modulation of acid-base transporters; however, the nature of the mechanisms underlying AVP direct action on intracellular pH (pH(i)) in the cortical ...
Nuclear receptors: a historical perspective
(Springer Nature Group, 2019-05)
These receptors exhibit a multitude of roles in cell biology and hence have attracted a great deal of interest in the drug discovery field. It is not certain whether these receptors evolved independently or an ancestral ...
Lovastatin differentially regulates α7 and α4 neuronal nicotinic acetylcholine receptor levels in rat hippocampal neurons
(Molecular Diversity Preservation International, 2020-10)
Neuronal α7 and α4β2 are the predominant nicotinic acetylcholine receptor (nAChR) subtypes found in the brain, particularly in the hippocampus. The effects of lovastatin, an inhibitor of cholesterol biosynthesis, on these ...
Anandamide regulates oxytocin/oxytocin receptor system in human placenta at term
(Elsevier, 2020-04)
Oxytocin plays a pivotal role in the regulation of human parturition, however its role and modulation in the placenta is not fully understood. Non-labour cesarean section placentas were cultured with the endocannabinoid ...
Ghrelin antagonist regulates metabolic hormone receptorsin the hypothalamus of ewes
(Elsevier, 2020-04)
This study evaluates the effects of ghrelin antagonist on mRNA abundance for metabolic hormone receptors in feed-restricted ewes. Ewes were randomly assigned to one of three treatments; Control (CO): feed above maintenance ...