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RUNX2 promueve la progresión tumor en osteosarcoma
(Universidad de Chile, 2011)
El Osteosarcoma (OS) es el tumor sólido maligno más frecuente en la
infancia y la adolescencia, corresponde al 20% de todos los tumores óseos y al
5% de los cánceres pediátricos. Los tratamientos actuales logran tasas ...
Niveles de RUNX2 en cáncer de ovario epitelial y efecto in vitro de los factores proangiogénicos NGF e hipoxia sobre sus niveles
(Universidad de Chile, 2016)
El cáncer ovárico epitelial (COE) es el cáncer ovárico más común, siendo en Chile la segunda causa de muerte por neoplasias ginecológicas.
Un aspecto importante para la mantención y progresión tumoral es el establecimiento ...
RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes
(Impact Journals, 2015-12)
Abstract Runx1 participation in epithelial mammary cells is still under review. Emerging data indicates that Runx1 could be relevant for breast tumor promotion. However, to date no studies have specifically evaluated the ...
Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts
(Wiley, 2019)
Expression of Runx2/p57 is a hallmark of the osteoblast-lineage identity. Although several regulators that control the expression of Runx2/p57 during osteoblast-lineage commitment have been identified, the epigenetic ...
Long Noncoding RNA TALAM1 Is a Transcriptional Target of the RUNX2 Transcription Factor in Lung Adenocarcinoma
(MDPI, 2023-09)
Background: Lung cancer is the leading cause of cancer death worldwide. It has been reported that genetic and epigenetic factors play a crucial role in the onset and evolution of lung cancer. Previous reports have shown ...
Las regiones de quiebre cromosomal localizadas en el locus del gen RUNX1 presentan módulos cis reguladores activos.
(Universidad de Concepción.Facultad de Ciencias BiológicasDepartamento de Biología Celular y Molecular., 2018)
RUNX1 es un factor de transcripción esencial en el desarrollo de la hematopoyesis y blanco frecuente de translocaciones cromosómicas asociadas al desarrollo de leucemias. A la fecha, el gen RUNX1 ha sido identificado en ...
RUNX1 deficiency (familial platelet disorder with predisposition to myeloid leukemia, FPDMM)
(Elsevier Inc, 2017-04)
In this review, we discuss disease-causing alterations of RUNT-related transcription factor 1 (RUNX1), a master regulator of hematopoietic differentiation. Familial platelet disorder with predisposition to myeloid leukemia ...
Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility
(2012-02-10)
Runt-related transcription factors (RUNX1, RUNX2, and RUNX3) are key lineage-specific regulators of progenitor cell growth and differentiation but also function pathologically as cancer genes that contribute to tumorigenesis. ...
C/EBPβ binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cells
(2011)
The Runx2 factor is an essential component of the regulatory mechanisms that control transcription during skeletogenesis. Runx2/p57 expression in osteoblastic cells is controlled by the P1 promoter, which is recognized by ...
C/EBPβ binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cells
(2011)
The Runx2 factor is an essential component of the regulatory mechanisms that control transcription during skeletogenesis. Runx2/p57 expression in osteoblastic cells is controlled by the P1 promoter, which is recognized by ...