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New insights into the control of neurotrophic growth factor receptor signaling: Implications for nervous system development and repair
(Wiley Blackwell Publishing, Inc, 2012-12)
Neurotrophic growth factors control neuronal development by activating specific receptor tyrosine kinase positive signaling pathways, such as Ras-MAPK and PI3K-Akt cascades. Once activated, neurotrophic factor receptors ...
Sprouty4 Is an Endogenous Negative Modulator of TrkA Signaling and Neuronal Differentiation Induced by NGF
(Public Library of Science, 2012-02)
The Sprouty (Spry) family of proteins represents endogenous regulators of downstream signaling pathways induced by receptor tyrosine kinases (RTKs). Using real time PCR, we detect a significant increase in the expression ...
Role of mesenchymal fibro/adipogenic progenitors in homeostasis and disease : from signaling to fibrosis
(2019)
Fibrosis, the dysregulated accumulation of connective tissue (CT), is a hallmark of
multiple pathologies where inflammation is not fully resolved. The main components of
the CT are the extracellular matrix (ECM) and its ...
Oncogenic role of arsenic exposure in lung cancer: A forgotten risk factor
(Facultad de Medicina y Ciencia, 2019)
Several drinkable water sources worldwide have been highly contaminated with arsenic, which means that an estimated 160 million people have been exposed to this chemical agent. If we analyse exposure by region, we will ...
Oncogenic role of arsenic exposure in lung cancer: A forgotten risk factor
(2019)
Several drinkable water sources worldwide have been highly contaminated with arsenic, which means that an estimated 160 million people have been exposed to this chemical agent. If we analyse exposure by region, we will ...
Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea
(2016-02)
While autonomic outflow is an important co-factor of nausea physiology, central control of this outflow is poorly understood. We evaluated sympathetic (skin conductance level) and cardiovagal (high-frequency heart rate ...