Now showing items 1-10 of 151
Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA
Cisplatin is one of the most effective and widely used chemotherapeutic agents against several types of human cancers. However, the underlying mechanisms of action are not fully understood. We aimed to investigate the ...
Knockdown of the c-Jun-N-terminal kinase expression by siRNA inhibits MCF-7 breast carcinoma cell line growth
We have examined the effect of two small interference RNA against Jnk-1 and Jnk-2 in the breast cancer cell line MCF-7. The expression of the JNK-1 and JNK-2 is frequently elevated in breast cancer and is a frequent genetic ...
Inhibition of JNK-1 by small interfering RNA induces apoptotic signaling in PC-3 prostate cancer cells
(SPANDIDOS PUBL LTD, 2012)
Inhibition of basal JNK activity by small interfering RNAs enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells
(Spandidos Publications, 2015)
Inhibition of basal Jun kinase (JNK) activity by small interfering RNAs (siRNAs) enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. Although the JNK pathway has been extensively studied in ...
Interferência por RNA: uma nova alternativa para terapia nas doenças reumáticas
(Sociedade Brasileira de Reumatologia, 2010-12-01)
RNA interference (RNAi) is a post-transcriptional gene silencing mechanism preserved during evolution. This mechanism, recently described, is mediated by small double-stranded RNAs (dsRNAs) that can specifically recognize ...