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The 3 ' Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA
(AMER SOC MICROBIOLOGY, 2010)
In the process of translation of eukaryotic mRNAs, the 5' cap and the 3' poly(A) tail interact synergistically to stimulate protein synthesis. Unlike its cellular counterparts, the small mRNA (SmRNA) of Andes hantavirus ...
Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes
(1998)
Guanine N-7 methylation is an essential step in the formation of the m7GpppN cap structure that is characteristic of eukaryotic mRNA 5' ends. The terminal 7-methylguanosine is recognized by cap-binding proteins that ...
Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4
(Oxford University Press, 2019)
Computational study on the allosteric mechanism of Leishmania major IF4E-1 by 4E-interacting protein-1: Unravelling the determinants of m7GTP cap recognition
(2021-01-01)
During their life cycle, Leishmania parasites display a fine-tuned regulation of the mRNA translation through the differential expression of isoforms of eukaryotic translation initiation factor 4E (LeishIF4Es). The interaction ...
The Elav-like protein HuR exerts translational control of viral internal ribosome entry sites
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009)
The human embryonic-lethal abnormal vision (ELAV)-like protein. HuR, has been recently found to be involved in the regulation of protein synthesis. In this study we show that HuR participates in the translational control ...
The Leishmania PABP1-eIF4E4 interface: a novel 5'-3' interaction architecture for trans-spliced mRNAs
(Oxford University Press, 2019)
The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA
(Oxford University Press, 2013)
Here, we show a novel molecular mechanism
promoted by the DEAD-box RNA helicase DDX3 for
translation of the HIV-1 genomic RNA. This occurs
through the adenosine triphosphate-dependent formation
of a translation initiation ...