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Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology
(John Wiley & Sons Inc, 2020-06-10)
Mathematical models are an important tool in pharmaceutical formulationsdevelopment, to evaluate in vitro and in vivo drug release processes and to optimize the design of new systems. Dome Matrix technology allows the ...
Differental effects of glatamate agonist and D-aspartate on oxytocin release from hypothalamus and posterior pituitary of male rats.
(Humana Press, 2001-12)
In order to determine whether ionotropic (iGluRs) and metabotropic (mGluRs) glutamate receptor activation modulates oxytocin release in male rats, we investigated the effect of agonists of both types of glutamate receptors ...
Multilayered electrospun nanofibrous scaffolds for tailored controlled release of embelin
(Taylor & Francis, 2018-01)
Polymeric electrospun meshes are highly attractive as versatile platforms for numerous biomedical applications, tissue engineering, biosensors, and controlled release of bioactive agents. Herein, we describe the preparation ...
PLGA based drug delivery systems (DDS) for the sustained release of insulin: Insight into the protein/polyester interactions and the insulin release behavior
(John Wiley & Sons Ltd, 2010-12)
BACKGROUND: Drug delivery systems (DDS) were designed using insulin as model drug and poly (lactic-co-glycolic) copolymers (PLGA) as polymeric matrix. The carriers were synthesized by direct self-assembly of the insulin ...
Flavor release by enzymatic hydrolysis of starch samples containing vanillin-amylose inclusion complexes
(Elsevier Science, 2014-05)
Hylon VII is a high amylose corn starch which has excellent gelling properties, and its behavior as flavor encapsulant is relevant to the food industry because its ability to regulate a swelling-controlled release in aqueous ...
Validation of kinetic modeling of progesterone release from polymeric membranes
(Shenyang Pharmaceutical University, 2018-01)
Mathematical modeling in drug release systems is fundamental in development and optimization of these systems, since it allows to predict drug release rates and to elucidate the physical transport mechanisms involved. In ...
Participation of the GABAergic system on the glutamate release of frontal cortex synaptosomes from Wistar rats with experimental autoimmune encephalomyelitis
(Pergamon-Elsevier Science Ltd, 2011-08)
We previously found that the glutamate release was decreased in synaptosomes from rat cerebral cortex during the development of experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis. Various ...
The effect of D-aspartate on luteinizing hormone-releasing hormone, α-melanocyte-stimulating hormone, GABA and dopamine release
(Lippincott Williams, 2002-12)
Since D-aspartate stimulates prolactin and LH release, our objective was to determine whether D-aspartate modifies the release of hypothalamic and posterior pituitary factors involved in the control of their secretion and ...
One-dimensional drug release from finite Menger sponges: In silico simulation
(Pergamon-Elsevier Science Ltd, 2009-12)
The purpose of this work was to evaluate the consequences of the spatial distribution of components in pharmaceutical matrices type Menger sponge on the drug release kinetic from this kind of platforms by means of Monte ...
Chitin nanowhiskers as alternative antimicrobial controlled release carriers
(Royal Society of Chemistry, 2015-01)
Antimicrobial finishings protect users from pathogenic and odor-generating microorganisms, which are of medical and hygiene concerns. Controlled release is a useful approach to obtain antimicrobial finishings in several ...