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Allosteric positive interaction of thymol with the GABA-A receptor in primary cultures of mouse cortical neurons
(Pergamon-Elsevier Science Ltd, 2006-01)
Thymol is a naturally occurring phenolic monoterpene known for its anti-microbial and anti-oxidant properties. It is used in dental practice and in anaesthetic halothane preparations. Recent studies have reported enhanced ...
GABAA Receptor Binding and Ion Channel Function in Primary Neuronal Cultures for Neuropharmacology/Neurotoxicity Testing
(Humana Press, 2011)
GABAA receptor (GABAAR) constitutes the main inhibitory receptor of the central nervous system. Due to the wide distribution and activity of its main neurotransmitter agonist, the γ-aminobutyric acid (GABA), its pharmacology ...
Activity of B-nor analogues of neurosteroids on the GABAA receptor in primary neuronal cultures
(American Chemical Society, 2006-06)
A GABAA receptor study of several B-nor analogues of allopregnanolone and pregnanolone has been carried out. B-Norallopregnanolone (i.e., 3α-hydroxy-7-nor-5α-pregnan-20-one) was found comparable to allopregnanolone when ...
Flavonoids as GABAA receptor ligands: the whole story?
(Dove Medical Press, 2012-01)
Benzodiazepines are the most widely prescribed class of psychoactive drugs in current therapeutic use, despite the important unwanted side effects that they produce, such as sedation, myorelaxation, ataxia, amnesia, and ...
Efecto inhibitorio de péptidos de defensa innata derivados de LL-37 en biopelícula de Staphylococcus spp.
(Instituto de BiotecnologíaUniversidad Nacional de Colombia - Sede Bogotá, 2020-02-27)
Los Staphylococcus spp. hacen parte de la microbiota humana, la patología depende de la capacidad de secretar toxinas, factores de virulencia y genes de resistencia.
Otro de los factores de resistencia es la formación de ...