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Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing
(Wiley-liss, Div John Wiley & Sons Inc, 2012-07)
Rac1b is an alternatively spliced isoform of the small GTPase Rac1 that includes the 57-nucleotide exon 3b. Rac1b was originally identified through its over-expression in breast and colorectal cancer cells, and has ...
The levels of RAC3 expression are up regulated by TNF in the inflammatory response
(Wiley, 2014-01)
RAC3 is a coactivator of glucocorticoid receptor and nuclear factor-κB (NF-κB) that is usually over-expressed in tumors and which also has important functions in the immune system. We investigated the role of the inflammatory ...
High RAC3 expression levels are required for induction and maintaining of cancer cell stemness
(Impact Journals, 2017-12)
RAC3 is a transcription coactivator, usually overexpressed in several tumors and required to maintain the pluripotency in normal stem cells. In this work we studied the association between RAC3 overexpression on cancer ...
Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinoma
(B M J Publishing Group, 2020-10)
Objective: The RHO family of GTPases, particularly RAC1, has been linked with hepatocarcinogenesis, suggesting that their inhibition might be a rational therapeutic approach. We aimed to identify and target deregulated RHO ...
The inflammatory cytokine TNF contributes with RAC3-induced malignant transformation
(Univ Mainz-med Dept, 2018-11)
RAC3 is a coactivator of steroid receptors and NF-kB. It is usually overexpressed in several tumors, contributes to maintain cancer stem cells and also to induce them when is overexpressed in non-tumoral cells. In this ...
FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
(Elsevier, 2021-11)
Despite the undisputable role of the small GTPase Rac1 in the regulation of actin cytoskeleton reorganization, the Rac guanine-nucleotide exchange factors (Rac-GEFs) involved in Rac1-mediated motility and invasion in human ...
Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines
(Impact Journals LLC, 2017-10)
Rac1 GTPase has long been recognized as a critical regulatory protein in different cellular and molecular processes involved in cancer progression, including acute myeloid leukemia. Here we show the antitumoral activity ...
RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition
(BioMed Central, 2017-11)
Background: RAC3 coactivator overexpression has been implicated in tumorigenesis, contributing to inhibition ofapoptosis and autophagy. Both mechanisms are involved in resistance to treatment with chemotherapeutic agents.The ...
RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis
(Elsevier Science, 2007-10)
The nuclear receptor coactivator RAC3 plays important roles in many biological processes and tumorigenesis. We found that RAC3 is over-expressed in human chronic myeloid leukemia cells K562, which are normally resistant ...
Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics
(Elsevier Science Inc, 2018-04)
Rac1 GTPase signaling pathway has a critical role in the regulation of a plethora of cellular functions governing cancer cell behavior. Recently, it has been shown a critical role of Rac1 in the emergence of resistance ...