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Crosstalk between Rac1-mediated actin regulation and ROS production
(Elsevier Inc., 2018)
© 2018 Elsevier Inc.The small RhoGTPase Rac1 is implicated in a variety of events related to actin cytoskeleton rearrangement. Remarkably, another event that is completely different from those related to actin regulation ...
Crosstalk between Rac1- mediated actin regulation and ROS production
(Elsevier, 2018)
The small RhoGTPase Rac1 is implicated in a variety of events related to actin cytoskeleton rearrangement. Remarkably, another event that is completely different from those related to actin regulation has the same relevance; ...
Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing
(Wiley-liss, Div John Wiley & Sons Inc, 2012-07)
Rac1b is an alternatively spliced isoform of the small GTPase Rac1 that includes the 57-nucleotide exon 3b. Rac1b was originally identified through its over-expression in breast and colorectal cancer cells, and has ...
The levels of RAC3 expression are up regulated by TNF in the inflammatory response
(Wiley, 2014-01)
RAC3 is a coactivator of glucocorticoid receptor and nuclear factor-κB (NF-κB) that is usually over-expressed in tumors and which also has important functions in the immune system. We investigated the role of the inflammatory ...
High RAC3 expression levels are required for induction and maintaining of cancer cell stemness
(Impact Journals, 2017-12)
RAC3 is a transcription coactivator, usually overexpressed in several tumors and required to maintain the pluripotency in normal stem cells. In this work we studied the association between RAC3 overexpression on cancer ...
La sobreexpresión de RAC3 es una señal transformante y proliferativa que contribuye al desarrollo tumoralRAC3 overexpression is a transforming and proliferative signal that contributes to tumoral development
(Medicina (buenos Aires), 2011-01)
RAC3 fue caracterizado originalmente como un coactivador de receptores nucleares que se encuentra en cantidades limitantes en células normales, aunque sobreexpresado en tumores y es además coactivador de NF-кB. Si bien se ...
Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinoma
(B M J Publishing Group, 2020-10)
Objective: The RHO family of GTPases, particularly RAC1, has been linked with hepatocarcinogenesis, suggesting that their inhibition might be a rational therapeutic approach. We aimed to identify and target deregulated RHO ...
The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility
(Rockefeller Univ Press, 2013-09-23)
Vaccinia virus dissemination relies on the N-WASP– ARP2/3 pathway, which mediates actin tail formation underneath cell-associated extracellular viruses (CEVs). Here, we uncover a previously unappreciated role for the formin ...
The inflammatory cytokine TNF contributes with RAC3-induced malignant transformation
(Univ Mainz-med Dept, 2018-11)
RAC3 is a coactivator of steroid receptors and NF-kB. It is usually overexpressed in several tumors, contributes to maintain cancer stem cells and also to induce them when is overexpressed in non-tumoral cells. In this ...
FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
(Elsevier, 2021-11)
Despite the undisputable role of the small GTPase Rac1 in the regulation of actin cytoskeleton reorganization, the Rac guanine-nucleotide exchange factors (Rac-GEFs) involved in Rac1-mediated motility and invasion in human ...