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Importance of monitoring and early switch to second generation tyrosine kinase inhibitors for the prognosis of patients with chronic myeloid leukemia with imatinib resistance or intolerance
(Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, 2011)
Imatinib mesylate was the first BCR-ABL-target agent approved for the treatment of chronic myeloid leukemia. Although most patients respond well to imatinib therapy, the literature shows that one third develops resistance ...
Importance of monitoring and early switch to second generation tyrosine kinase inhibitors for the prognosis of patients with chronic myeloid leukemia with imatinib resistance or intolerance
(Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula ÓsseaBrasil, 2011)
Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis
(BioMed Central, 2017)
Abstract
Background
The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been ...
Purine and pyrimidine phosphoribosyltransferases: A versatile tool for enzymatic synthesis of nucleoside-5′-monophosphates
(Current Pharmaceutical Design, 2019)
Effects of 5-Cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine (BAY 41-2272) on smooth muscle tone, soluble guanylyl cyclase activity, and NADPH oxidase Activity/Expression in corpus cavernosum from wild-type, neuronal, and endothelial nitric-oxide synthase null mice
(Amer Soc Pharmacology Experimental TherapeuticsBethesdaEUA, 2007)
A relação entre fragmentos estruturais oriundos de produtos naturais e compostos bioativos
(2015-01-01)
This review aims to highlight some structural fragments derived from natural products, which are present in several bioactive compounds, most of them used as drugs. In this context, are described the amino acids, purines ...
Design and synthesis of chemosensors based on 7-ferrocenylpyrazolo[1,5-a]pyrimidines for the detection of H+ and CN-
(Universidad de los AndesMaestría en QuímicaFacultad de CienciasDepartamento de Química, 2021-12)
This work investigates the rational design of novel chemosensors based on hybrid inorganic/organic structures for detecting H+ and CN-. The synthesis of chemosensors that integrate ferrocene and pyrazolo[1,5-a]pyrimidine ...
4-Formilpirazoles y 3-formilpirazolo[1,5-a]pirimidinas como precursores de potenciales agentes antifúngicos fluorescentes
(Universidad de los AndesDoctorado en Ciencias - QuímicaFacultad de CienciasDepartamento de Química, 2022-05-25)
En este documento se presentan los resultados del trabajo de investigación de Doctorado en Ciencias-Química titulado "4-formilpirazoles y 3-formilpirazolo[1,5-a]pirimidinas como precursores de potenciales agentes antifúngicos ...
Caracterização da enzima citidina monofosfato quinase (EC 2.7.4.14) de Mycobacterium tuberculosis H37Rv como alvo para o desenvolvimento de drogas para o tratamento da tuberculose
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2013)
Tuberculosis (TB), one of the oldest recorded human afflictions, is still one of the biggest killers among the infectious diseases. The HIV co-infection and the emergence of multidrug resistant TB have provided a very ...