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New biocatalysts for one pot multistep enzymatic synthesis of pyrimidine nucleoside diphosphates from readily available reagents
(Elsevier Science, 2015-04)
Since the preparation of nucleoside 5′-diphosphates by classical methodologies is complex, multistep enzymatic systems were explored to synthesize pyrimidine nucleoside 5′-diphosphates starting from readily available ...
Developing a collection of immobilized nucleoside phosphorylases for the preparation of nucleoside analogues: Enzymatic synthesis of arabinosyladenine and 2',3'-dideoxyinosine
(Wiley, 2013-02)
The use of nucleoside phosphorylases (NPs; EC 2.4.2.n) represents a convenient alternative to the chemical route for the synthesis of natural and modified nucleosides. We purified four recombinantly expressed nucleoside ...
Purine and pyrimidine phosphoribosyltransferases: A versatile tool for enzymatic synthesis of nucleoside-5′-monophosphates
(Current Pharmaceutical Design, 2019)
Coupled biocatalysts applied to the synthesis of nucleosides
(Oxford University Press, 2008-09)
Abstract Biocatalytic procedures offer a good alternative to the chemical synthesis of nucleosides since biocatalyzed reactions are regio- and stereoselective and afford reduced by-products contents. Among them, enzymatic ...
An improved microbial synthesis of purine nucleosides
(Springer, 2000-07)
E. coli BL21 synthesized purine nucleosides from pyrimidine ones. A 94% yield of adenosine from uridine was reached within 1 h.
Expression and distribution of nucleoside transporter proteins in the human syncytiotrophoblast
(2011)
The plasma membrane distribution and related biological activity of nucleoside transporter proteins (NTs) were investigated in human syncytiotrophoblast from term placenta using a variety of approaches, including nucleoside ...
Interaction of low-energy electrons with the pyrimidine bases and nucleosides of DNA
(Amer Inst PhysicsMelvilleEUA, 2007)
Synthesis of conformationally locked carbocyclic nucleosides built on an oxabicyclo[3.1.0]hexane system
(Pergamon-Elsevier Science Ltd, 2003-01)
The rigid 6-oxobicyclo[3.1.0]hexane scaffold, characteristic of the natural antibiotic neplanocin C (3), was used to build prototypes of conformationally locked deoxynucleosides in the North hemisphere of the pseudorotational ...
Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011)
Equilibrative nucleoside transporters (ENTs) are facilitative transporters broadly selective for pyrimidine and purine nucleosides and are essential for the modulation of nucleoside concentration and nucleoside analog ...