Now showing items 1-10 of 35
Insularinase A, a prothrombin activator from Bothrops insularis venom, is a metalloprotease derived from a gene encoding protease and disintegrin domains
(Walter de Gruyter Gmbh, 2005-06-01)
The first low-molecular-mass metalloprotease presenting prothrombin activating activity was purified from Bothrops insularis venom and named insularinase A. It is a single-chain protease with a molecular mass of 22 639 Da. ...
Reversal of the anticoagulant and anti-hemostatic effect of low molecular weight heparin by direct prothrombin activation
(Associação Brasileira de Divulgação Científica (ABRADIC), 2012-10-01)
Lopap, found in the bristles of Lonomia obliqua caterpillar, is the first exogenous prothrombin activator that shows serine protease-like activity, independent of prothrombinase components and unique lipocalin reported to ...
In vivo characterization of Lopap, a prothrombin activator serine protease from the Lonomia obliqua caterpillar venom
(Elsevier B.V., 2001-06-01)
Increasing occurrence of hemorrhagic syndrome in man, caused by contact with Lonomia obliqua caterpillars, has been reported in Southern Brazil in the past 10 years. the L. obliqua venom causes a severe consumptive ...
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin
Both human and bovine prothrombin fragment 2 (the second kringle) have been cocrystallized separately with human PPACK (D-Phe-Pro-Arg)-thrombin, and the structures of these noncovalent complexes have been determined and ...
Terapia com warfarina em pacientes cardiológicos
O uso do pool de plasma caseiro interfere no valor da rni?
Introduction: The prothrombin time (PT) test is commonly used to monitor anticoagulant levels in patients undergoing oral anticoagulant therapy. Currently, anticoagulation levels have been assessed through the international ...
Factor V Leiden and factor II G20210A mutations in patients with recurrent abortion
Recurrent abortion (RA) represents an intriguing problem in obstetric practice in which genetic and acquired factors may play a role. In the present investigation we sought to assess the possibility that inherited thrombophilia ...
A prothrombin activator from Bothrops erythromelas (jararaca-da-seca) snake venom: characterization and molecular cloning
(Portland Press, 2003-01-01)
A novel prothrombin activator enzyme, which we have named 'berythractivase', was isolated from Bothrops erythromelas (jararaca-da-seca) snake venom. Berythractivase was purified by a single cation-exchange-chromatography ...
Tuberculosis: an uncommon cause of cerebral venous thrombosis?
(Academia Brasileira de Neurologia - ABNEURO, 2005-09-01)
Several infectious etiologies are related to cerebral venous thrombosis (CVT), but a review of literature showed only few cases related to tuberculosis (TB), and only one with neurological manifestations.We report an unusual ...