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An ensemble framework for identifying essential proteins
(2016-08-25)
Background: Many centrality measures have been proposed to mine and characterize the correlations between network topological properties and protein essentiality. However, most of them show limited prediction accuracy, and ...
Protein intrinsic disorder and network connectivity. The case of 14-3-3 proteins
(Frontiers, 2014-02)
The understanding of networks is a common goal of an unprecedented array of traditional disciplines. One of the protein network properties most influenced by the structural contents of its nodes is the inter-connectivity. ...
Complex networks: the key to systems biology
(Sociedade Brasileira de Genética, 2008)
Though introduced recently, complex networks research has grown steadily because of its potential to represent, characterize and model a wide range of intricate natural systems and phenomena. Because of the intrinsic ...
MicrobioLink: An Integrated Computational Pipeline to Infer Functional Effects of Microbiome-Host Interactions
(2020-05-21)
Microbiome-host interactions play significant roles in health and in various diseases including autoimmune disorders. Uncovering these inter-kingdom cross-talks propels our understanding of disease pathogenesis and provides ...
Collective variable driven molecular dynamics to improve protein protein docking scoring
(Elsevier, 2013-12-28)
In biophysics, the structural prediction of protein–protein complexes starting from the unbound form of the two interacting monomers is a major difficulty. Although current computational docking protocols are able to ...
H-bond refinement for electron transfer membrane-bound protein-protein complexes: cytochrome c oxidase and cytochrome c552
(Elsevier, 2013-06)
In this study we propose a protocol to evaluate membrane-bound cytochrome c oxidase–cytochrome c552 docking candidates. An initial rigid docking algorithm generates docking poses of the cytochrome c oxidase–cytochrome c552, ...
The Protein Interactome Of Collapsin Response Mediator Protein-2 (crmp2/dpysl2) Reveals Novel Partner Proteins In Brain Tissue
(WILEY-V C H VERLAG GMBHWEINHEIM, 2015)
Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins
(Academic Press Inc Elsevier ScienceSan DiegoEUA, 2006)