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The Cross-talk Between Angiotensin And Insulin Differentially Affects Phosphatidylinositol 3-kinase- And Mitogen-activated Protein Kinase-mediated Signaling In Rat Heart: Implications For Insulin Resistance.

Carvalheira, José B C; Calegari, Vivian C; Zecchin, Henrique G; Nadruz, Wilson; Guimarães, Regina B; Ribeiro, Eliane B; Franchini, Kleber G; Velloso, Lício A; Saad, Mario J A (2003)

Early Activation Of The Multicomponent Signaling Complex Associated With Focal Adhesion Kinase Induced By Pressure Overload In The Rat Heart.

Franchini, K G; Torsoni, A S; Soares, P H; Saad, M J (2000)

Novel Signal Transduction Pathway For Luteinizing Hormone And Its Interaction With Insulin: Activation Of Janus Kinase/signal Transducer And Activator Of Transcription And Phosphoinositol 3-kinase/akt Pathways.

Carvalho, Carla R O; Carvalheira, José B C; Lima, Maria H M; Zimmerman, Suzana F; Caperuto, Luciana C; Amanso, Angélica; Gasparetti, Alessandra L; Meneghetti, Vainer; Zimmerman, Leonardo F; Velloso, Licio A; Saad, Mario J A (2003)

Akt/PKB: one kinase, many modifications

Risso, Guillermo; Blaustein Kappelmacher, Matias; Pozzi, María Berta; Mammi, Pablo Andrés; Srebrow, Anabella (Portland Press, 2015-06)

Akt/PKB, a serine/threonine kinase member of the AGC family of proteins, is involved in the regulation of a plethora of cellular processes triggered by a wide diversity of extracellular signals and is thus considered a key ...

Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region

Plotz, Guido; Lopez-Garcia, Laura A.; Brieger, Angela; Zeuzem, Stefan; Biondi, Ricardo Miguel (Public Library of Science, 2020-11)

Three AKT serine/threonine kinase isoforms (AKT1/AKT2/AKT3) mediate proliferation, metabolism, differentiation and anti-apoptotic signals. AKT isoforms are activated downstream of PI3-kinase and also by PI3-kinase independent ...

Effect Of Obesity On Insulin Signaling Through Jak2 In Rat Aorta.

Gottardello Zecchin, Henrique; De Souza, Claudio Teodoro; Oliveira Prada, Patrícia; Campello Carvalheira, José Barreto; Augusto Velloso, Licio; Abdalla Saad, Mario José (2005)

Colocalized delivery of rapamycin and paclitaxel to tumors enhances synergistic targeting of the PI3K/Akt/mTOR pathway

Carlos Alberto González Delgado

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

Riggio, Marina; Perrone, María C.; Polo, María L.; Rodríguez, María J.; May, María; Abba, Martín Carlos; Lanari, Claudia; Novaro, Virginia (2017)

Study of PI3K/AKT/mTOR pathway in breast cancer progression

Novaro, Virginia (Instituto de Histología y Embriología, 2018)

Deregulation in the PI3K/AKT/mTOR pathway is associated with breast cancer development. Using experimental models of breast carcinogenesis induced in mice, xenografts of tumor cell lines, and tumors from patients we found ...

Regulation Of Insulin Receptor Substrate-2 Tyrosine Phosphorylation In Animal Models Of Insulin Resistance.

Rojas, Fernanda Alvarez; Hirata, Aparecida Emiko; Saad, Mario J A (2003)

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