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Salivary gland morphology, tissue tropism and the progression of tospovirus infection in Frankliniella occidentalis
(2016)
Tomato spotted wilt virus (TSWV) is transmitted by thrips in a propagative manner; however, progression of virus infection in the insect is not fully understood. The goal of this work was to study the morphology and infection ...
Recent treatment advances in HER2-positive metastatic breast cancer: a clinical approach
(2012-05)
The use of targeted therapy directed against HER2 is currently the standard of care in patients with metastatic HER2-positive breast cancer. The combination of trastuzumab with a taxane as first-line treatment in HER2-positive ...
Tissue Inhibitor of Metalloproteinase-1 Is Confined to Tumor-Associated Myofibroblasts and Is Increased With Progression in Gastric Adenocarcinoma
(2016)
The tissue inhibitor of metalloproteinase-1 (TIMP-1) inhibits the extracellular matrix–degrading activity of several matrix metalloproteinases, thereby regulating cancer cell invasion and metastasis. Studies describing the ...
High levels of somatic DNA diversity at the myotonic dystrophy type 1 locus are driven by ultra-frequent expansion and contraction mutations
(Human Molecular Genetics, 2012, Vol. 21, No. 11 2450–2463, 2012-02-24)
Several human genetic diseases are associated with inheriting an abnormally large unstable DNA simple sequence
repeat. These sequences mutate, by changing the number of repeats, many times during the lifetime
of those ...
The Need for Full Integration of Snakebite Envenoming within a Global Strategy to Combat the Neglected Tropical Diseases: The Way Forward
(2013-06-13)
Snakebite envenoming constitutes a serious medical condition that primarily affects residents of rural communities in Africa, Asia, Latin America, and New Guinea [1], [2]. It is an occupational, environmental, and domestic ...
Norrie Disease Gene Mutation in a Large Costa Rican Kindred With a Novel Phenotype Including Venous Insufficiency
(1997)
A large Costa Rican kindred has been identified with 15 males affected with congenital blindness, progressive hearing loss, and venous insufficiency. Due to ophthalmological and audio-otological findings, including bilateral ...
Women's Health in Central America: The Complexity of Issues and the Need to Focus on Indigenous Healthcare
(2013-04)
The Central American (CA) isthmus consists of seven countries including Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua and Panama, some of the poorest countries in the world. Over the past ...
El uso de animales de experimentación en la investigación biomédica en Costa Rica
(Acta Médica Costarricense 52(3), 2010-07)
El progreso en la investigación médica y biológica ha dependido en gran medida del uso de animales
experimentales Dada la importancia que históricamente han tenido los animales como reactivos
biológicos en la investigación ...
Bothrops asper: Beauty and peril in the Neotropics
(2009-12-01)
Snakes have inspired fascination and fear to humans since ancient times, as reflected by the common presence of these reptiles in the mythology of many civilizations. Such sense of awe has been associated to the impact ...