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Type A Insulin Resistance Syndrome- Novel insulin receptor gene mutation and familiar phenotypic variability
(Peertechz Publications, 2019-06)
Type A Insulin Resistance Syndrome is due to heterozygous mutations in the insulin receptor (INSR) gene or its signaling pathway. We present a premenarcheal 14 year-old girl with normal BMI, severe hirsutism, acanthosis ...
(-)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress
(Elsevier Science Inc, 2014-07)
We investigated the capacity of dietary (-)-epicatechin (EC) to mitigate insulin resistance through the modulation of redox-regulated mechanisms in a rat model of metabolic syndrome (MetS). Adolescent rats were fed a regular ...
Prenatal stress promotes insulin resistance without inflammation or obesity in C57BL/6J male mice
(Taylor & Francis Ltd, 2021-09)
During gestation, stress exposure increases the risk of developing cognitive and physiological alterations in either the long or short term. Among them, metabolic alterations have been described. Adipose tissue is responsible ...
Hepatic cyclooxygenase-2 expression protects against diet-induced steatosis, obesity and insulin resistance
(American Diabetes Association, 2015-01)
Accumulation evidence links obesity-induced inflammation as an important contributor to the development of insulin resistance which plays a key role in the pathophysiology of obesity-related diseases such as type 2 diabetes ...
Grape pomace and grape pomace extract improve insulin signaling in high-fat-fructose fed rat-induced metabolic syndrome
(Royal Society of Chemistry, 2016-03)
In this study the effect of diet supplementation with grape pomace (GP) and grape pomace extract (GPE) on insulin sensitive tissues (adipose, liver and muscle) was evaluated in an experimental model of metabolic syndrome ...
Prenatal testosterone exposure induces insulin resistance, uterine oxidative stress and pro-inflammatory status in rats
(Elsevier Ireland, 2020-01)
Prenatal androgen excess is considered one of the main causes of the development of polycystic ovary syndrome. In this study, we investigated the effect of prenatal hyperandrogenization (PH) on the physiology of the adult ...
Dietary fish oil ameliorates adipose tissue dysfunction in insulin-resistant rats fed a sucrose-rich diet improving oxidative stress, peroxisome proliferator-activated receptor γ and uncoupling protein 2
(Royal Society of Chemistry, 2018-04)
This work aimed to assess the possible beneficial effects of dietary fish oil (FO) on the preexisting adipose tissue dysfunction through the improvement or reversion of the mechanisms underlying oxidative stress and ...
Losartan prevents the imbalance between renal dopaminergic and renin angiotensin systems induced by fructose overload. L-Dopa/dopamine index as new potential biomarker of renal dysfunction
(W B Saunders Co-Elsevier Inc, 2018-08)
Background: The renin angiotensin system (RAS) and the renal dopaminergic system (RDS) act as autocrine and paracrine systems to regulate renal sodium management and inflammation and their alterations have been associated ...
Disruption of tumor necrosis factor alpha receptor 1 signaling accelerates NAFLD progression in mice upon a high-fat diet
(Elsevier Science Inc, 2018-08)
Obesity is accompanied by a low-grade inflammation state, characterized by increased proinflammatory cytokines levels such as tumor necrosis factor alpha (TNFα) and interleukin-1 beta (IL-1β). In this regard, there exists ...
Neuroendocrine, metabolic, and immune functions during the acute phase response of inflammatory stress in monosodium L-glutamate-damaged, hyperadipose male rat
(Karger, 2008-10)
In rats, neonatal treatment with monosodium L-glutamate (MSG) induces several metabolic and neuroendocrine abnormalities, which result in hyperadiposity. No data exist, however, regarding neuroendocrine, immune and metabolic ...