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Análogos de insulina: en búsqueda del reemplazo fisiológico
(Sociedad Médica de Santiago, 2006)
Insulin analogues: Searching for a physiological replacement Análoges de insulina: En búsqueda del reemplazo fisiológico
Insulin analogues, developed by molecular engineering, have structural changes in the A and B insulin chains. These modifications change their action profile, rendering insulin replacement closer to physiology. Rapid acting ...
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis
Background: Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. ...
TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient - Effects on leptin and insulin signaling pathways
(Elsevier B.V., 2007-05-01)
Acting in the hypothalamus, tumor necrosis factor-alpha (TNF-alpha) produces a potent anorexigenic effect. However, the molecular mechanisms involved in this phenomenon are poorly characterized. In this study, we investigate ...
Effects of melatonin on insulin signaling and inflammatory pathways of rats with apical periodontitis
Aim: To verify the effects of melatonin supplementation on insulin sensitivity, plasma concentrations of inflammatory cytokines, insulin signalling and inflammatory pathways in the soleus (SM) and extensor digitorum longus ...
Cytoprotective and suicidal signaling in oxidative stress
(Society of Biology of Chile, 2010)
Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this ...
Adrenarche in Prader-Willi syndrome appears not related to insulin sensitivity and serum adiponectin
Prader-Willi syndrome (PWS) is a genetic disorder characterized by dysmorphic features, obesity, hypogonadism, hypotonia and mental retardation. Obesity has been linked to insulin resistance and the latter has also been ...
Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitis
In vertebrates, the inflammatory reaction is responsible for modulating the initial nonspecific defense until specific immunity is acquired. In this context, numerous studies in mammals have demonstrated the participation ...