Now showing items 1-10 of 440
Análogos de insulina: en búsqueda del reemplazo fisiológico
(Sociedad Médica de Santiago, 2006)
Insulin analogues: Searching for a physiological replacement Análoges de insulina: En búsqueda del reemplazo fisiológico
Insulin analogues, developed by molecular engineering, have structural changes in the A and B insulin chains. These modifications change their action profile, rendering insulin replacement closer to physiology. Rapid acting ...
Pro-angiogenic role of insulin: from physiology to pathology
The underlying molecular mechanisms involve in the regulation of the angiogenic process by insulin are not well understood. In this review article, we aim to describe the role of insulin and insulin receptor activation on ...
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis
Background: Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. ...
TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient - Effects on leptin and insulin signaling pathways
(Elsevier B.V., 2007-05-01)
Acting in the hypothalamus, tumor necrosis factor-alpha (TNF-alpha) produces a potent anorexigenic effect. However, the molecular mechanisms involved in this phenomenon are poorly characterized. In this study, we investigate ...
Exercise Increases Insulin Sensitivity Related To Obesity By Reducing The Pro-Inflammatory Biomarkers In Rat Skeletal Muscle
(Lippincott Williams & Wilkins, 2013-05-01)
Type A Insulin Resistance Syndrome- Novel insulin receptor gene mutation and familiar phenotypic variability
(Peertechz Publications, 2019-06)
Type A Insulin Resistance Syndrome is due to heterozygous mutations in the insulin receptor (INSR) gene or its signaling pathway. We present a premenarcheal 14 year-old girl with normal BMI, severe hirsutism, acanthosis ...
Cytoprotective and suicidal signaling in oxidative stress
(Society of Biology of Chile, 2010)
Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this ...