mechanistic understanding of the diverse clinical manifestations of Parkinson's disease (PD) and variable patient response to treatments is lacking. Genetically diverse PD model organisms can be used to map modifier genes ...

Introduction: Drug repositioning implies finding new medical uses for existing drugs. It represents a cost-efficient approach, since the new indications are built on the basis of available information on pharmacokinetics, ...

Purpose/Background. To present the concatenation of medical digitalization that unravels from the goal of therapeutic improvement through precision medicine and moves on to enhancement medicine beyond the normal function ...

La medicina de precisión se presenta en los países centrales como un nuevo paradigma en el tratamiento de algunas enfermedades. Basada en el conocimiento del genoma de cada individuo, se sustenta en el principio de que el ...

Abstract: Pathologies linked to the renin angiotensin system are frequent, and the drugs used in them are numerous and show great variability in therapeutic effects and adverse reactions. Genetic variants have been detected ...

This review aims to provide an updated perspective of epilepsy genetics and precision medicine in adult patients, with special focus on developmental and epileptic encephalopathies (DEEs), covering relevant and controversial ...