Buscar
Mostrando ítems 1-10 de 220
Validation of a Phage Display Method for Protease Inhibitor Selection Using SFTI and HiTI Synthetic Hybrid Peptides
(Bentham Science Publ Ltd, 2010-11-01)
A recombinant Haematobia irritans irritans trypsin inhibitor (HiTI - Mw 7030 kDa) phagemid library was constructed and displayed functionally on the tip of the filamentous M13 phage. A combinatorial library of 7.2 x 10(6) ...
BmSI-7, a novel subtilisin inhibitor from Boophilus microplus, with activity toward Pr1 proteases from the fungus Metarhizium anisopliae
(Elsevier B.V., 2008-02-01)
BmSI-7 and BmSI-6, two Boophilus microplus subtilisin inhibitors (BmSI) were purified and characterized from eggs. the inhibitors isolated by classical purification methods presented molecular masses of 7408 and 7271 Da, ...
Proteases and their inhibitors in coagulation and inflammation
(Atena Editora, 2020)
Proteases ou peptidases são moléculas que promovem a clivagem através da hidrólise de ligações peptídicas presentes em proteínas e polipeptídeos, transformando os em resíduos de aminoácidos ou polipeptídeos menores. O grupo ...
Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts
(AMER SOC INVESTIGATIVE PATHOLOGY, 2004-11)
The main event in the pathogenesis of prion diseases is the conversion of the cellular prion protein (PrPC) into the abnormal, protease-resistant prion protein (PrPres). PrPC is a GPI-anchored protein located in lipid rafts ...
Design and use of highly specific substrates of neutrophil elastase and proteinase 3
(Amer Thoracic Soc, 2004-06-01)
We have exploited differences in the structures of S2' subsites of proteinase 3 (Pr3) and human neutrophil elastase (FINE) to prepare new fluorogenic substrates specific for each of these proteases. the positively charged ...
Proteolytic activity, degradation, and dissolution of primary and permanent teeth
(2020-09-01)
Background: Primary and permanent teeth composition may influence dissolution and degradation rates. Aim: To compare the dissolution and degradation of primary and permanent teeth. Design: Enamel and dentin powders were ...
Proteolytic activity, degradation, and dissolution of primary and permanent teeth
(Wiley-Blackwell, 2020-09-01)
Background Primary and permanent teeth composition may influence dissolution and degradation rates. Aim To compare the dissolution and degradation of primary and permanent teeth. Design Enamel and dentin powders were ...
Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1
(BIOSCIENTIFICA LTD, 2012)
Progesterone and progestins have been demonstrated to enhance breast cancer cell migration, although the mechanisms are still not fully understood. The protease-activated receptors (PARs) are a family of membrane receptors ...
Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates
(Amer Soc Biochemistry Molecular Biology Inc, 2002-10-18)
Human neutrophil elastase (HNE) has long been linked to the pathology of a variety of inflammatory diseases and therefore is a potential target for therapeutic intervention. At least two other serine proteases, proteinase ...