Now showing items 1-10 of 128
Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation
(International Research Journals Publishing House, 2011-09)
The aim of this work was to explore the potential of combining two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride for their utilization in the design of thermosensitive injectable depot systems ...
Dissolution Enhancement and Characterization of Nimodipine Solid Dispersions with Poloxamer 407 or PEG 6000
(TAYLOR & FRANCIS INCPHILADELPHIA, 2012)
The solid dispersion approach is an alternative to increase drug solubility. Many carriers have been studied, but there is few information about poloxamer 407 (P407). Consequently, the objective of this study was to evaluate ...
A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery
(ELSEVIER SCIENCE BV, 2010)
The aim of the present work was to obtain an ophthalmic delivery system with improved mechanical and mucoadhesive properties that could provide prolonged retention time for the treatment of ocular diseases. For this, an ...
Osteoinductivity potential of rhBMP-2 associated with two carriers in different dosages
The objective of this study was to evaluate bone formation after application of different doses of recombinant human bone morphogenetic protein-2 (rhBMP-2) combined with monoolein or poloxamer gels, in critical bone defects ...
Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary use
(Colegio Farmaceuticos Provincia de Buenos Aires, 2010-12)
The purpose of this work is to explore the potential of combining poloxamer 407 and carrageenan for its utilization in an injectable depot drug release system. Reverse thermal gelation of these formulations allow the local ...
Formulações De S-nitrosotióis Doadores De óxido Nìtrico Incorporados Em Géis Aquosos Térmicamente Reversìveis De Copolìmero Tribloco De Poli (óxido De Etileno) Pluronic F-127 Ou Poloxamer 407 E Metodologia De Incorporação De S-nitrosotióis Em Matrizes De Géis Aquosos De Pluronic F-127 Ou Poloxamer 407
A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages
(Elsevier B.V., 2018)
© 2018 Elsevier B.V. Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In ...