Now showing items 1-10 of 188
Evolution of the Metazoan Mitochondrial Replicase
(Oxford Univ Press, 2015-04-01)
The large number of complete mitochondrial DNA (mtDNA) sequences available for metazoan species makes it a good system for studying genome diversity, although little is known about the mechanisms that promote and/or are ...
Roles of the mitochondrial replisome in mitochondrial DNA deletion formation
(Soc Brasil Genetica, 2020-01-01)
Mitochondrial DNA (mtDNA) deletions are a common cause of human mitochondrial diseases. Mutations in the genes encoding components of the mitochondrial replisome, such as DNA polymerase gamma (Pol gamma) and the mtDNA ...
Introduction to foamability study of a LDPE subjected to gamma radiation
(Aptor Software, 2022)
Remdesivir triphosphate blocks DNA synthesis and increases exonucleolysis by the replicative mitochondrial DNA polymerase, Pol γ
The COVID-19 pandemic prompted the FDA to authorize a new nucleoside analogue, remdesivir, for emergency use in affected individuals. We examined the effects of its active metabolite, remdesivir triphosphate (RTP), on the ...