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Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp)
(Taylor & Francis Ltd, 2018-01)
Congenital platelet function disorders are often the result of defects in critical signal transduction pathways required for platelet adhesion and clot formation. Mutations affecting RASGRP2, the gene encoding the Rap ...
Establishment of the first platelet-donor registry in Argentina
(Società Italiana di Medicina Trasfusionale e Immunoematologia, 2020-07)
Background: Platelet transfusions are necessary to prevent and treat haemorrhages in thrombocytopenic patients or those with severe platelet dysfunction. In Latin American countries, including Argentina, blood supplies ...
Downregulation of TREM-like transcript (TLT)-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia
(Ferrata Storti Foundation, 2018-12)
Germline RUNX1 mutations lead to thrombocytopenia and platelet dysfunction in familialplatelet disorder with predisposition to acute myelogenous leukemia. Multiple aspects ofplatelet function are impaired in these patients, ...
Platelets Bioenergetics Screening Reflects the Impact of Brain Aβ Plaque Accumulation in a Rat Model of Alzheimer
(Springer/Plenum Publishers, 2019-06)
Alzheimer’s disease (AD) is associated to depressed brain energy supply and impaired cortical and hippocampal synaptic function. It was previously reported in McGill-R-Thy1-APP transgenic (Tg(+/+)) rats that Aβ deposition ...
Platelets as mediators of Thromboinflammation in chronic Myeloproliferative Neoplasms
(Frontiers Research Foundation, 2019-06-14)
Chronic myeloproliferative neoplasms (MPN) are stem cell disorders driven by mutations in JAK2, CALR, or MPL genes and characterized by myeloid proliferation and increased blood cell counts. They encompass three closely ...
Poly (I:C) downregulates platelet production and function through type I interferon
(Schattauer Gmbh-Verlag Medizin Naturwissenschaften, 2015-07)
Thrombocytopaenia is a frequent complication of viral infections; the underlying mechanisms appear to depend on the identity of the virus involved. Previous research, including reports from our group, indicates that as ...
Impaired frequencies and function of platelets and tissue remodeling in chronic Chagas disease
(Public Library of Science, 2019-06)
Chronic inflammation, as a consequence of the persistent infection with Trypanosoma cruzi, leads to continuous activation of the immune system in patients with chronic Chagas disease. We have previously shown that increased ...
Effects of Salvia hispanica L. (chia) seed on blood coagulation, endothelial dysfunction and liver fibrosis in an experimental model of Metabolic Syndrome
(Royal Society of Chemistry, 2021-12)
The aim of this study was to analyze blood coagulation, endothelial dysfunction and liver fibrosis in an experimental model of Metabolic Syndrome (MS) induced by chronic administration of a sucrose-rich diet (SRD) and to ...
Cirrhosis, von Willebrand Factor (vWF) and the low incidence of metastatic malignancy in injured liver
(Atatürk University. Faculty of Medicine, 2015-10)
The work by Yilmaz et al. in The Eurasian Journal of Medicine provides clinical evidence for the correlation between increased levels of von Willebrand factor (vWF) and the stage of cirrhosis. The authors observed significantly ...