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Alteration in cellular viability, pro-inflammatory cytokines and nitric oxide production in nephrotoxicity generation by Amphotericin B: Involvement of PKA pathway signaling
(2013-10-11)
Amphotericin B is one of the most effective antifungal agents; however, its use is often limited owing to adverse effects, especially nephrotoxicity. The purpose of this study was to evaluate the effect of inhibiting the ...
cAMP-PKA signal transduction specificity in Saccharomyces cerevisiae
(Springer, 2020-09)
Living cells have developed a set of complex signaling responses, which allow them to withstand different environmental challenges. Signaling pathways enable the cell to monitor external and internal states and to articulate ...
Regulatory role of the PKA pathway in dimorphism and mating in Yarrowia lipolytica
(Academic Press Inc Elsevier Science, 2009-05)
Previous studies on the dimorphic transition of Yarrowia lipolytica suggested opposite roles for MAPK and PKA pathways in this phenomenon. To obtain conclusive evidences for these opposite roles we isolated and disrupted ...
Identification of novel transcriptional regulators of PKA subunits in Saccharomyces cerevisiae by quantitative promoter-reporter screening
(Wiley Blackwell Publishing, Inc, 2016-08)
The cAMP-dependent protein kinase (PKA) signaling is a broad pathway that plays important roles in the transduction of environmental signals triggering precise physiological responses. However, how PKA achieves the cAMP-signal ...
Computational chemical analysis of unconjugated bilirubin anions and insights into pKa values clarification
(American Institute of Physics, 2013-11)
The pKa, the negative logarithm of the acid dissociation equilibrium constant, of the carboxylic acid groups of unconjugated bilirubin in water is a discussed issue because there are quite different experimental values ...
An ACTH-activated protein tyrosine phosphatase (PTP) is modulated by PKA-mediated phosphorylation
(Taylor, 2000-11)
In adrenal cortex, ACTH regulation of steroidogenesis depends on PKA-dependent serine/threonine phosphorylation and also on the activity of protein tyrosine phosphatases (PTPs). In addition, ACTH increases total PTPs ...
Hormone-regulated PKA activity in porcine oviductal epithelial cells
(Springer, 2020-02)
The oviduct is a dynamic organ that suffers changes during the oestrous cycle and modulates gamete and embryo physiology. We analyse the possible existence of Protein kinase A (PKA)-dependent hormone-regulated pathways in ...
The role of PKA and PKC epsilon pathways in prostaglandin E(2)-mediated hypernociception
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Background and purpose: Protein kinase (PK) A and the epsilon isoform of PKC (PKC epsilon) are involved in the development of hypernociception (increased sensitivity to noxious or innocuous stimuli) in several animal models ...