The effect of pinealectomy (PIN-X) and PIN-X + melatonin treatment during pregnancy (PIN-X + MEL) 100 μg/100 g body weight on Substance P (SP) in the striatum was investigated in offspring female rats. Female offspring ...

A considerable number of studies have demonstrated the anticonvulsant effect of melatonin. the present study examines the influence of pinealectomy on the amygdala kindling development in rats. Animals were divided into ...

Melatonin, the main hormone produced by the pineal gland, is secreted in a circadian manner (24-hr period), and its oscillation influences several circadian biological rhythms, such as the regulation of clock genes expression ...

Clinical investigations suggest that melatonin suppression and circadian dysfunction may be related to cancer development in shift workers. Studies also show that melatonin suppression after pinealectomy increases cancer ...

The aim of the present work was to analyze c-fos response within the trigeminal nucleus caudalis (TNC) of pinealectomized rats and animals that received intraperitoneal melatonin, after intracisternal infusion of capsaicin, ...

Regardless of the molecular and physiological mechanisms involved, maternal fetal circadian systems interactions are recognized as crucial crosstalk for fetal development, and in turn, it may be a key factor determining ...

In rodents, during late embryonic and early neonatal development, circadian rhythms develop in synchrony with those of their mothers, which in turn are synchronized with the environmental photoperiod. This paper examines ...