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The catalytic subunit of schizosaccharomyces pombe CK2 (Cka1) negatively regulates RNA polymerase II transcription through phosphorylation of positive cofactor 4 (PC4)
(MDPI, 2022)
Positive cofactor 4 (PC4) is a transcriptional coactivator that plays important roles in
transcription and DNA replication. In mammals, PC4 is phosphorylated by CK2, and this event
downregulates its RNA polymerase II ...
Membrane actions of male contraceptive gossypol tautomers
(1986)
The role of different gossypol tautomers in the interaction of this molecule with membranes has been investigated using the isolated hemiacetal moiety of gossypol and the pH dependency of the keto-enol tautomeric equilibrium. ...
The phosphorylation of nucleoplasmin by casein kinase-2 is resistant to heparin inhibition
(1987)
Highly purified preparations of casein kinase-2 from the nuclei of Xenopus laevis oocytes and from calf thymus can phosphorylate in vitro purified nucleoplasmin from X. laevis oocytes and eggs. The phosphorylation of ...
Chemical dissection of the APC repeat 3 multistep phosphorylation by the concerted action of protein kinases CK1 and GSK3
(2007)
A crucial event in machinery controlled by Wnt signaling is the association of β-catenin with the adenomatous polyposis coli (APC) protein, which is essential for the degradation of β-catenin and requires the multiple ...
Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons
(2007)
Hydrogen peroxide, which stimulates ERK phosphorylation and synaptic plasticity in hippocampal neurons, has also been shown to stimulate calcium release in muscle cells by promoting ryanodine receptor redox modification ...
The first armadillo repeat is involved in the recognition and regulation of beta-catenin phosphorylation by protein kinase CK1
(NATL ACAD SCIENCES, 2006-12-26)
Multiple phosphorylation of beta-catenin by glycogen synthase kinase 3 (GSK3) in the Wnt pathway is primed by CK1 through phosphorylation of Ser-45, which lacks a typical CK1 canonical sequence. Synthetic pepticles ...
Effect of glutamate receptor phosphorylation by endogenous protein kinases on electrical activity of isolated postsynaptic densities of rat cortex and hippocampus
(Elsevier Ireland Ltd, 1997)
Postsynaptic densities (PSDs) were isolated from rat brain cortex and hippocampus, purified and incorporated into giant (5-80 μm in diameter) liposomes. Gigaohm seals were obtained with a patch-clamp pipette, and a giant ...
Kinetic, chromatographic and electrophoretic studies on glucose-phosphorylating enzymes of rat intestinal mucosa
(1984)
The number and nature of glucose-phosphorylating enzymes of rat intestinal mucosa were investigated by chromatographic, electrophoretic, and kinetic methods. Three fractions with glucose-phosphorylating activity were ...
Analysis of rotavirus non-structural protein NSP5 by mass spectrometry reveals a complex phosphorylation pattern
(ELSEVIER, 2010)
Genomic replication and partial assembly of Rotavirus takes place in cytoplasmic viral structures called
viroplasms. NSP5 is a viral phosphoprotein localized in viroplasms and its expression is imperative for
viral cycle ...
Tau Phosphorylation by cdk5 and Fyn in Response to Amyloid Peptide A beta(25-35): Involvement of Lipid Rafts
(IOS PRESS, 2009)
Alzheimer’s disease (AD) is characterized by the accumulation of protein filaments, namely extracellular amyloid-β
(Aβ) fibrils and intracellular neurofibrillary tangles, which are composed of aggregated hyperphosphorylated ...