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Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin
(Taylor & Francis, 2016)
From its introduction in 1952 onwards, the clinical use of macrolides has been steadily increasing, both in human and veterinary medicine. Although initially designed to the treatment of Gram-positive microorganisms, this ...
Entinostat (SNDX-275) for the treatment of non-small cell lung cancer
(Taylor & Francis, 2015)
INTRODUCTION: Epigenetic aberrations play an important role in lung carcinogenesis. Chromatin deacetylation is a fundamental mechanism of gene silencing. Histone deacetylase (HDAC) inhibitors are an emerging class of ...
Cysticidal Efficacy of Combined Treatment With Praziquantel and Albendazole for Parenchymal Brain Cysticercosis
(Oxford University Press, 2016)
BACKGROUND: The efficacy of current antiparasitic treatment for cerebral Taenia solium cysticercosis with either albendazole (ABZ) or praziquantel (PZQ) is suboptimal. A recent study demonstrated that combining these 2 ...
Quality assurance for antimicrobial susceptibility testing of Neisseria gonorrhoeae in Latin American and Caribbean countries, 2013-2015
(BMJ Publishing Group, 2018)
OBJECTIVES: A Neisseria gonorrhoeae antimicrobial susceptibility quality control comparison programme was re-established in Latin America and the Caribbean to ensure antimicrobial susceptibility data produced from the ...
Combined therapies for Duchenne muscular dystrophy to optimize treatment efficacy
(Frontiers Media, 2018-04)
Duchene Muscular Dystrophy (DMD) is the most frequent muscular dystrophy and one of the most severe due to the absence of the dystrophin protein. Typical pathological features include muscle weakness, muscle wasting, ...
Relationship Between Eslicarbazepine Exposure And Efficacy Of Eslicarbazepine Acetate Adjunctive Therapy
(SPRINGER/PLENUM PUBLISHERSNEW YORK, 2015)
Reposição de volume na sepse com solução salina hipertônica
(Associação de Medicina Intensiva Brasileira - AMIB, 2008)
Esta revisão discute os efeitos hemodinâmicos e imunomoduladores da solução hipertônica em choque experimental e em pacientes com sepse. Comentamos sobre os mecanismos de ação da solução hipertônica, recorrendo a dados ...