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Cancer pharmacogenetics: Study of genetically determined variations on cancer susceptibility due to xenobiotic exposure Farmacogenética del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióti
(2006)
Pharmacogenetics is the study of genetically determined variations in the response to drugs and toxic agents, and their implications on disease. Recently, the discipline has acquired great relevancy due to the development ...
Cardiovascular pharmacogenomics: Clinical applications in Latin America
(Nova Science Publishers, Inc., 2017)
© 2011 by Nova Science Publishers, Inc. All rights reserved. Cardiovascular diseases (CVDs) are the number one cause of death globally. Most cardiovascular diseases can be prevented by addressing behavioral risk factors ...
Methotrexate pharmacogenetics in Uruguayan adults with hematological malignant diseases
(Elsevier, 2017)
Background: Individual variability is among the causes of toxicity and interruption of treatment in acute lymphoblastic
leukemia (ALL) and severe non-Hodgkin lymphoma (NHL) patients under protocols including
Methotrexate ...
Clinical pharmacogenomics in South America
(Nova Science Publishers, Inc., 2017)
© 2011 by Nova Science Publishers, Inc. All rights reserved.In South America, in recent years, some studies have established allelic frequencies of the most relevant pharmacogenes. Several studies in South America have ...
Genetic Variants of Cytochrome CYP2D6 in Two Mixed Chilean Populations
(S. Karger AG, 2017)
© 2017 S. Karger AG, Basel. Objectives: It is known that the interindividual and interethnic variability of the genetic polymorphisms of CYP2D6 plays an important role in the presentation of adverse drug reactions and ...
Farmacogenómica como herramienta fundamental para la medicina personalizada: aplicaciones en la práctica clínica
(Sociedad Médica de Santiago, 2017)
Pharmacogenomics is an emergent field aimed at tailoring pharmacological
therapy. Genetic polymorphisms can modify the expression and
function of enzymes and proteins involved in drug metabolism, affecting
absorption, ...
State of art of cancer pharmacogenomics in Latin American populations
(MDPI AG, 2017)
Over the past decades, several studies have shown that tumor-related somatic and germline
alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present
a vast geno-phenotypic diversity ...
Epithelial-mesenchymal transition and microRNAs in colorectal cancer chemoresistance to FOLFOX
(MDPI, 2021)
The FOLFOX scheme, based on the association of 5-fluorouracil and oxaliplatin, is the most frequently indicated chemotherapy scheme for patients diagnosed with metastatic colorectal cancer. Nevertheless, development of ...
La farmacogenómica en medicina
(2012-02-24)
Introducción: La farmacogenómica estudia la forma como las variaciones del genoma influyen en la respuesta a
medicamentos. Su principal valor médico consiste en: i) la identificación de individuos en quienes se puede ...