Now showing items 1-10 of 171
Can pharmacogenetics explain efficacy and safety of cisplatin pharmacotherapy?
(Frontiers Media S.A., 2014)
© 2014 Roco, Cayún, Contreras, Stojanova and Quiñones.Several recent pharmacogenetic studies have investigated the variability in both outcome and toxicity in cisplatin-based therapies. These studies have focused on the ...
Cancer pharmacogenetics: Study of genetically determined variations on cancer susceptibility due to xenobiotic exposure Farmacogenética del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióti
Pharmacogenetics is the study of genetically determined variations in the response to drugs and toxic agents, and their implications on disease. Recently, the discipline has acquired great relevancy due to the development ...
Pharmacogenetics in the treatment of pre-eclampsia: Current findings, challenges and perspectives
Pre-eclampsia (PE) is defined as pregnancy-induced hypertension and proteinuria, and is a major cause of maternal and perinatal morbidity and mortality. A large subgroup of pregnant women with PE is nonresponsive to ...
La farmacogenómica en medicina
The incorporation of clinical guidelines of pharmacogenomics in Latin America
(Nova Science, 2017)
In Latin America the Pharmacogenetics and Pharmacogenomics areas are recently emerging fields and the main focus of the research is to evaluate ethnic differences to apply adapted guidelines to manage personalized ...
Uses and misuses of definitions of genetic polymorphism: A perspective from population pharmacogenetics
Definitions of genetic polymorphism currently employed in the pharmacological literature have been incorrectly used (Kalow, 1984) and uncritically imported from population genetics [e.g., Weinshilboum (1984), Evans (1977)], ...
An update on the pharmacogenetics of treating hypertension
(Nature Publishing Group, 2015-05-01)
Hypertension is a leading cause of cardiovascular mortality, but only one third of patients achieve blood pressure goals despite antihypertensive therapy. Genetic polymorphisms may partially account for the interindividual ...
Pharmacogenetics, tobacco, alcohol and its effect on the risk development cancer Farmacogenética, tabaco, alcohol y su efecto sobre el riesgo de desarrollar cáncer
(Sociedad Chilena de Pediatria, 2018)
© 2018, Sociedad Chilena de Pediatria. All rights reserved. Cancer is the second leading cause of death in the world, causing 8.8 million deaths in 2015 according to the World Health Organization (WHO). Risk factors for ...