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Solid-phase peptide synthesis in highly loaded conditions
(Academic Press Inc. Elsevier B.V., 2011-02-01)
The use of very highly substituted resins has been avoided for peptide synthesis due to the aggravation of chain-chain interactions within beads. To better evaluate this problem, a combined solvation-peptide synthesis ...
Solid-phase peptide synthesis in highly loaded conditions
(Elsevier B.V., 2011-02-01)
The use of very highly substituted resins has been avoided for peptide synthesis due to the aggravation of chain-chain interactions within beads. To better evaluate this problem, a combined solvation-peptide synthesis ...
Solid-phase peptide synthesis at elevated temperatures: a search for an optimized synthesis condition of unsulfated cholecystokinin-12
(Munksgaard Int Publ Ltd, 1997-08-01)
A systematic investigation of solid-phase peptide synthesis at elevated temperatures using the well-known aggregating peptide acyl carrier protein (65-74) and the unsulfated cholecystokinin-8 as models is presented. The ...
Comparative investigation of the cleavage step in the synthesis of model peptide resins: Implications for N-alpha-9-fluorenylmethyloxycarbonyl-solid phase peptide synthesis
(Pharmaceutical Soc Japan, 2007-03-01)
Based on our studies of the stability of model peptide-resin linkage in acid media, we previously proposed a rule for resin selection and a final cleavage protocol applicable to the N-alpha-tert-butyloxycarbonyl (Boc)-peptide ...
Multiple bradykinin-related peptlides from the capture web of the spider Nephila clavipes (Araneae, Tetragnatidae)
(Elsevier B.V., 2006-04-01)
Three bradykinin-related peptides (nephilakinins-I to -III) and bradykinin itself were isolated from the aqueous washing extract of the capture web of the spider Nephila clavipes by gel permeation chromatography on a ...
Study of the effect of the peptide loading and solvent system in SPPS by HRMAS-NMR
(Wiley-Blackwell, 2005-09-01)
The SPPS methodology has continuously been investigated as a valuable model to monitor the solvation properties of polymeric materials. In this connection, the present work applied HRMAS-NMR spectroscopy to examine the ...
EPR investigation of the influence of side chain protecting groups on peptide-resin solvation of the Asx and Glx model containing peptides
(Elsevier B.V., 2007-07-30)
In spite of all progressive efforts aiming to optimize SPPS, serious problems mainly affecting the assembly of aggregating sequences have persisted. Following the study intended to unravel the complex solvation phenomenon ...
EPR investigation of the influence of side chain protecting groups on peptide-resin solvation of the Asx and Glx model containing peptides
(Elsevier B.V., 2007-07-30)
In spite of all progressive efforts aiming to optimize SPPS, serious problems mainly affecting the assembly of aggregating sequences have persisted. Following the study intended to unravel the complex solvation phenomenon ...
Synthesis and pharmacological properties of TOAC-labeled angiotensin and bradykinin analogs
(Elsevier B.V., 2002-01-01)
Angiotensin II (AngII) and bradykinin (BK) derivatives containing the TOAC (2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid) spin label were synthesized by solid phase methodology. Ammonium hydroxide (pH 10, ...