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Characteristics, Properties and Analytical Methods of Paclitaxel: A Review
Paclitaxel is a diterpenoid pseudoalkaloid, isolated from Taxus brevifolia, and is largely used as an antitumoral drug. The formulation of paclitaxel known as Taxol® employs a mixture of Cremophor EL and dehydrated ethanol, ...
Use of cholesterol-rich nanoparticles that bind to lipoprotein receptors as a vehicle to paclitaxel in the treatment of breast cancer: pharmacokinetics, tumor uptake and a pilot clinical study
Purpose In animal experiments paclitaxel oleate associated with a cholesterol-rich nanoemulsion concentrated in the neoplastic tissues and showed reduced toxicity and increased antitumor activity compared with paclitaxel-Cremophor ...
Obtenção e caracterização de microesferas de copolímero PLDLA contendo paclitaxel
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-graduação em Ciências dos Materiais (campus SOROCABA), 2013-02-05)
In order to minimize the side effects of chemotherapy concurrently with the enhancement of its therapeutic action is to use it on devices that enable a controlled drug release, by vectors, such as polymeric microspheres, ...
Curcumin and paclitaxel induce cell death in breast cancer cell lines
(Spandidos Publications, 2019)
Estudo dos efeitos da terapia combinada orlistat / cisplatina / 5-fluorouracil / paclitaxel em linhagem metastática de carcinoma espinocelular de línguaEffects of combined therapy Orlistat / Cisplatin/ 5-Fluorouracil / Paclitaxel in metastatic lineage of squamous cell carcinoma of the tongue
DM-1, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate: a curcumin analog with a synergic effect in combination with paclitaxel in breast cancer treatment
This paper describes a new method for the preparation of sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate, DM-1, and 3-oxo-penta-1,4-dienyl-bis (2-methoxy-phenolate), DM-2. The aim of ...
Paclitaxel associated with cholesterol-rich nanoemulsions promotes atherosclerosis regression in the rabbit
(ELSEVIER IRELAND LTD, 2008)
A cholesterol-rich nanoemulsion (LDE) that resembles LDL binds to the LDL receptors and after injection into the blood stream may concentrate in cells with LDL receptor overexpression, as occurs in neoplasias and other ...
Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin- induced cytotoxicity
(BioMed Central, 2014-04)
BACKGROUND: Antiprogestin compounds have been shown to be effective in blocking the growth of ovarian cancer cells of different genetic backgrounds. Herein we studied the anti-ovarian cancer effect of a series of antiprogestins ...