Prenylated flavonoids are an important class of naturally occurring flavonoids with important biological activity, but their low abundance in nature limits their application in medicines. Here, we showed the hemisynthesis ...

Multidrug resistance (MDR) in the opportunistic pathogen Candida albicans is defined as non-susceptibility to at least one agent in two or more drug classes. This phenomenon has been increasingly reported since the rise ...

Chalcones form a class of compounds that belong to the flavonoid family and are widely distributed in plants. Their simple structure and the ease of preparation make chalcones attractive scaffolds for the synthesis of a ...

The antioxidant effect of 8PP, a prenylflavonoid from Dalea elegans on Candida albicans biofilms, was investigated. We previously reported that sensitive (SCa) and resistant C. albicans (RCa) biofilms were strongly inhibited ...

Neurodegenerative diseases (NDs) represent a global problem on public health, with a growing incidence as human longevity increases. Currently, although there are palliative strategies available for most of these diseases, ...

Three compounds: (2S)-8-(3″-methylbut-2″-enyl)-7,3′,4′-trihydroxyflavanone, (2S)-8-(3″-methyl-4″-hydroxy-but-2″-enyl)-7,3′,4′-trihydroxyflavanone and (2S)-8-(3″-methyl-4″-hydroxy-but-2″-enyl)-5,3′,4′-trihydroxy-7-methoxyflavanone, ...