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A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis
(WILEY, 2008)
Peroxisome proliferator activated receptors (PPARs, alpha, beta/delta, gamma) control lipid homeostasis and differentiation in various tissues and tumor cells. PPAR beta and PPAR gamma increase oligodendrocyte maturation ...
PPAR alpha and PPAR gamma regulate the nucleoside transporter hENT1
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2012)
Human equilibrative nucleoside transporter 1 (hENT1) is an important determinant for nucleoside analog based chemotherapy success. Preliminary data suggest hENT1 regulation by PPARs. Using A2780 cells, we investigated the ...
New PPAR alpha/gamma/delta Optimal Activator Rationally Designed by Computational Methods
(Soc Brasileira Quimica, 2016-09-01)
The peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that acts as a transcription factor, regulating glucose, lipid and inflammation signaling and it is exploited in type 2 diabetes ...
Upregulation of rat liver PPAR alpha-FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol
(2016)
Prevention of ischemia-reperfusion liver injury is achieved by a combined omega-3 and thyroid hormone (T-3) protocol, which may involve peroxisome-proliferator activated receptora (PPAR-alpha)-fibroblast growth factor 21 ...
Ppar alpha and ppar gamma regulate the nucleoside transporter hent1
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2012)
Megalin/LRP2 Expression Is Induced by Peroxisome Proliferator-Activated Receptor -Alpha and -Gamma: Implications for PPARs' Roles in Renal Function
(PUBLIC LIBRARY SCIENCE, 2011)
Background: Megalin is a large endocytic receptor with relevant functions during development and adult life. It is expressed at the apical surface of several epithelial cell types, including proximal tubule cells (PTCs) ...
Changes in gene expression in PBMCs profiles of PPAR alpha target genes in obese and non-obese individuals during fasting
(Karger, 2015-01-01)
Background: The prevalence of obesity has risen dramatically and the World Health Organization estimates that 700 million people will be obese worldwide by 2015. Approximately, 50% of the Brazilian population above 20 years ...
Structural Insights into Human Peroxisome Proliferator Activated Receptor Delta (PPAR-Delta) Selective Ligand Binding
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
Peroxisome proliferator activated receptors (PPARs delta, alpha and gamma) are closely related transcription factors that exert distinct effects on fatty acid and glucose metabolism, cardiac disease, inflammatory response ...