Polyamines play critical roles as regulators of cell growth and differentiation. In contrast with other protozoa, the human parasite Trypanosoma cruzi, the etiological agent of Chagas disease, is auxotrophic for polyamines. ...

The development of new chemical entities against the major diseases caused by parasites is highly desired. A library of thirty diamines analogs following a minimalist approach and supported by chemoinformatics tools have ...

Visceral leishmaniasis (VL) is the second-largest parasitic killer disease in the world, responsiblefor near one million infections each year. Polyamines are ubiquitous organic molecules that play key roles in kinetoplastids ...

In this Letter we present the synthesis of hitherto unreported 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines 1. Cyclic amidines 1 were synthesized by PPSE promoted ring closure of N-acyl-N0-arylpentamethylenediamines ...

In this Letter we present a method for the synthesis of N-acyl-N´-arylhexahydropyrimidines 1, by ring closure of N-acyl-N´-aryl-1,3-propanediamines 3 with formaldehyde. Cyclodehydrations were performed in aqueous medium ...

There is evidence that while polyamines facilitate seizures by positively modulating N-methyl-D-aspartate receptors (NMDAr), selective antagonists of the NR2B-subunit decrease seizures. However, it remains undetermined ...

Las poliaminas, principalmente putrescina y espermidina, son metabolitos esenciales para la supervivencia de Trypanosoma cruzi, el agente etiológico de la enfermedad de Chagas. Particularmente este parásito es incapaz de ...