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Metabolism of Poly-ADP-ribose in Trypanosomatids
(Nova Science Publishers, Inc, 2010)
The poly-ADP-ribosylation reaction is a post-translational modification involved invarious cellular processes including DNA repair, DNA replication, gene expression,maintenance of genomic stability, cell death and cellular ...
Host Cell Poly(ADP-ribose) glycohydrolase Is Crucial for Trypanosoma cruzi Infection Cycle
(Public Library Science, 2013-06-12)
Trypanosoma cruzi, etiological agent of Chagas´ disease, has a complex life cycle which involves the invasion of mammalian host cells, differentiation and intracellular replication. Here we report the first insights into ...
Poly(ADP-ribose) metabolism in human parasitic protozoa
(Elsevier Science, 2020-08-22)
Poly(ADP-ribosyl)ation reactions constitute a post-translational protein modification synthesized in higher eukaryotes by a family of poly(ADP-ribose)polymerases (PARP) and catabolized mainly by poly(ADP-ribose) glycohydrolase ...
ADP-ribosylation: From molecular mechanisms to human disease
(Sociedade Brasileira de Genética, 2020-01)
Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of ...
Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: Enzyme inhibition by β-lapachone
(Elsevier Science, 2001-12)
Crithidia fasciculata poly(ADP-ribose)polymerase (PARP) has been isolated and partially purified. This is the first PARP isolated from trypanosomatids; it requires DNA and histone for activity, using NAD+ as substrate. ...
Analysis of knockout mutants reveals non-redundant functions of poly(ADP-ribose)polymerase isoforms in Arabidopsis
(Plant Molecular Biology, 2017)
Clonado, caracterización y estudios funcionales de las enzimas poli (ADP-ribosa)polimerasa y poli (ADP-ribosa) glicohidrolasa de Trypanosoma bruceiCloning, characterization and functional studies of poly (ADP-ribose) polymerase and poly (ADP-ribose) glycohydrolase enzimes of Trypanosoma brucei
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2015)