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The Trypanosoma brucei RNA-Binding protein TbRRM1 is involved in the transcription of a subset of RNA Pol II-Dependent genes
(Wiley Blackwell Publishing, Inc, 2019-09)
It has been long thought that RNA Polymerase (Pol) II transcriptional regulation does not operate in trypanosomes. However, recent reports have suggested that these organisms could regulate RNA Pol II transcription by ...
Argonaute2 attenuates active transcription by limiting RNA Polymerase II elongation in Drosophila melanogaster
(Nature, 2018-12)
Increasing lines of evidence support that Argonaute2 (AGO2) harbors several nuclear functions in metazoa. In particular, Drosophila AGO2 modulates transcription of developmentally regulated genes; however, the molecular ...
Transcriptional elongation and alternative splicing
(Elsevier Science, 2013-01)
Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional, ...
How Slow RNA Polymerase II Elongation Favors Alternative Exon Skipping
(Cell Press, 2014-05)
Splicing is functionally coupled to transcription, linking the rate of RNA polymerase II (Pol II) elongation and the ability of splicing factors to recognize splice sites (ss) of various strengths. In most cases, slow Pol ...
Contrasting roles of the RSC and ISW1/CHD1 chromatin remodelers in RNA polymerase II elongation and termination
(Cold Spring Harbor Laboratory Press, 2019-03)
Most yeast genes have a nucleosome-depleted region (NDR) at the promoter and an array of regularly spaced nucleosomes phased relative to the transcription start site. We have examined the interplay between RSC (a conserved ...
First come, first served revisited: Factors affecting the same alternative splicing event have different effects on the relative rates of intron removal
(Cold Spring Harbor Laboratory Press, 2010-05)
Alternative splicing accounts for much of the complexity in higher eukaryotes. Thus, its regulation must allow for flexibility without hampering either its specificity or its fidelity. The mechanisms involved in alternative ...
Progesterone Receptor induces bcl-x expression through intragenic binding sites favoring RNA Polymerase II elongation
(Oxford University Press, 2013-05-02)
Steroid receptors were classically described for regulating transcription by binding to target gene promoters. However, genome-wide studies reveal that steroid receptors-binding sites are mainly located at intragenic ...
Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation
(Nature Publishing Group, 2013-08)
Alternative splicing contributes to cell type-specific transcriptomes. Here, we show that changes in intragenic chromatin marks affect NCAM (neural cell adhesion molecule) exon 18 (E18) alternative splicing during neuronal ...
p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled
(American Society for Microbiology, 2006-12)
We have previously reported that when DNA replication is blocked in some human cell lines, p53 is impaired in its ability to induce a subset of its key target genes, including p21(WAF1/CIP1). Here, we investigated the ...
Light Regulates Plant Alternative Splicing through the Control of Transcriptional Elongation
(Cell Press, 2019-03)
Light makes carbon fixation possible, allowing plant and animal life on Earth. We have previously shown that light regulates alternative splicing in plants. Light initiates a chloroplast retrograde signaling that regulates ...