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Stimulating effect of palmitate and insulin on cell migration and proliferation in PNT1A and PC3 prostate cells: Counteracting role of metformin
(2018-07-01)
Background: A potential association between obesity and prostate cancer has been proposed. Metformin, an antidiabetes drug, has antiproliferative effects being proposed for cancer treatment. However, under intense proliferative ...
Aglycone flavonoid brachydin A shows selective cytotoxicity and antitumoral activity in human metastatic prostate (DU145) cancer cells
(2021-01-01)
In prostate cancer, flavonoids possess a wide variety of anticancer effects, focused on the antioxidant/pro-oxidant activity, inactivation of the androgen receptor, cell cycle arrest, apoptosis induction, metastasis ...
Genotoxicity and cytotoxicity of sevoflurane in two human cell lines in vitro with ionizing radiation.
(2015-02-10)
Objective: To determine the in vitro toxicity of different concentrations of sevoflurane in cells exposed to X-ray.
Methods: The genotoxic effects of sevofluorane were studied by means of the micronucleus test in ...
Docosahexaenoic acid differentially modulates the cell cycle and metabolism- related genes in tumor and pre-malignant prostate cells
(Elsevier B.V., 2020-10-01)
Prostate cancer (PCa) has different molecular features along progression, including androgen profile, which is associated to therapy inefficiency leading to more aggressive phenotype. Docosahexaenoic acid (DHA) has ...
Melatonin and Docosahexaenoic Acid Decrease Proliferation of PNT1A Prostate Benign Cells via Modulation of Mitochondrial Bioenergetics and ROS Production
(Hindawi Ltd, 2019-01-01)
Prostate cancer development has been associated with changes in mitochondria' activity and reactive oxygen species (ROS) production. Melatonin (MLT) and docosahexaenoic acid (DHA) have properties to modulate both, but their ...
AKT and AMPK Activation after High-Fat and High-Glucose In Vitro Treatment of Prostate Epithelial Cells
(Georg Thieme Verlag Kg, 2014-06-01)
Considering the increasing consumption of saturated fat and glucose in diets worldwide and its possible association to carcinogenesis, this investigation analysed the proliferation profile of nonmalignant human prostate ...
Receptores estrogênicos regulam a expressão e a função de β-catenina e Galectina-3 em células de câncer de próstata independentes de androgênios DU-145
(Universidade Federal de São Paulo, 2022-05-12)
O câncer prostático inicialmente responde bem à terapia de ablação androgênica, mas em muitos casos o tumor progride para um fenótipo independente de androgênios ou também denominado resistente à castração (CRPC, castration ...
Identification of differentially expressed miRNAs in human cells infected with different Zika virus strains
(2021-01-01)
Infection with distinct Zika virus (ZIKV) strains in in vitro and in vivo models has demonstrated that the host’s response to infection is strain-dependent. There has been no analysis of the impact of infection with different ...
Insulin-loaded liposomes functionalized with cell-penetrating peptides: influence on drug release and permeation through porcine nasal mucosa
(2021-08-05)
The nasal route is promising for the delivery of insulin for diabetes treatment. Drug loading into delivery systems such as liposomes can improve the bioavailability of insulin for this route. Herein, we address the ...
The effect of 1,10-phenanthroline on the chromosome damage and sister-chromatid exchanges induced by streptozotocin in mammalian and insect cells
(Elsevier Science, 2000-02)
The effect of the metal chelating agent 1,10-Phenanthroline (PNT) on the streptozotocin (STZ)-induced chromosomal aberrations (CAs) and sister- chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) and mosquito (Aedes ...