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Centella asiatica water extract inhibits iPLA(2) and cPLA(2) activities in rat cerebellum
(ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2008)
Centella asiatica (L.) Urb an is distributed widely in South America and Asia and is known as a therapeutic agent in folk medicine, capable of improving memory and treating several neurological disorders. Asiaticoside is ...
Intranasal delivery of zidovudine by PLA and PLA-PEG blend nanoparticles
(Elsevier B.V., 2010-08-16)
This study describes the preparation and evaluation of biodegradable poly(L-lactide) (PLA) and poly(L, lactide)-poly(ethylene glycol) (PLA-PEG) blend nanoparticles containing zidovudine as model drug. The prepared nanoparticles ...
Intranasal delivery of zidovudine by PLA and PLA-PEG blend nanoparticles
(Elsevier B.V., 2010-08-16)
This study describes the preparation and evaluation of biodegradable poly(L-lactide) (PLA) and poly(L, lactide)-poly(ethylene glycol) (PLA-PEG) blend nanoparticles containing zidovudine as model drug. The prepared nanoparticles ...
Modificação química de poli(ácido láctico) com anidrido maleico por processamento reativo
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Ciência e Engenharia de Materiais - PPGCEM, 2014-08-18)
The chemical modification of PLA with maleic anhydride by reactive processing and the extent of reaction and degradation reactions, were studied. Routes of grafting reaction of maleic anhydride in PLA were evaluated. Dicumyl ...
Preparation and characterization of biomaterials based on poly lactic acid pla with the incorporation of nanoparticles for applications in biomedicinePreparación y caracterización de biomateriales basado en poli ácido láctico pla con la incorporación de nanopartículas para aplicaciones en biomedicina
(2020)
In the present Ph.D thesis work, poly (lactic acid) scaffolds with incorporation of nanoparticles were obtained through the electrospinning method for their potential application in bone tissue regeneration therapies. The ...
Neutralisation of the pharmacological activities of Bothrops alternatus venom by anti-PLA2 IgGs
(Elsevier, 2014-05)
Basic phospholipases A2 (PLA2) are toxic and induce a wide spectrum of pharmacological effects, although the acidic enzyme types are not lethal or cause low lethality. Therefore, it is challenging to elucidate the mechanism ...
A structure based model for liposome disruption and the role of catalytic activity in myotoxic phospholipase A(2)S
(Elsevier B.V., 2003-12-15)
Venom phospholipase A(2)s (PLA(2)s) display a wide spectrum of pharmacological activities and, based on the wealth of biochemical and structural data currently available for PLA(2)S, mechanistic models can now be inferred ...
A structure based model for liposome disruption and the role of catalytic activity in myotoxic phospholipase A(2)S
(Elsevier B.V., 2003-12-15)
Venom phospholipase A(2)s (PLA(2)s) display a wide spectrum of pharmacological activities and, based on the wealth of biochemical and structural data currently available for PLA(2)S, mechanistic models can now be inferred ...