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Identification of epsilon PKC Targets During Cardiac Ischemic Injury
(JAPANESE CIRCULATION SOCKYOTO, 2012)
Background: Epsilon-protein kinase C (epsilon PKC) protects the heart from ischemic injury. However, the mechanism(s) of epsilon PKC cardioprotection is still unclear. Identification of the epsilon PKC targets may aid in ...
Ischaemic preconditioning improves proteasomal activity and increases the degradation of delta PKC during reperfusion
(OXFORD UNIV PRESS, 2010)
The response of the myocardium to an ischaemic insult is regulated by two highly homologous protein kinase C (PKC) isozymes, delta and epsilon PKC. Here, we determined the spatial and temporal relationships between these ...
The pros and cons of targeting Protein Kinase C (PKC) in the management of cancer patients
(Bentham Science Publishers, 2011-11)
In the last years, PKC has become an attractive target for the treatment of cancer patients given its widely described role in carcinogenesis and tumor promotion. Despite the extensive research conducted on these phorbol ...
The role of PKA and PKC epsilon pathways in prostaglandin E(2)-mediated hypernociception
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Background and purpose: Protein kinase (PK) A and the epsilon isoform of PKC (PKC epsilon) are involved in the development of hypernociception (increased sensitivity to noxious or innocuous stimuli) in several animal models ...
Identification of εPKC targets during cardiac ischemic injury
(National Institute of Health, 2017)
PKC beta II inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses
(WILEY-BLACKWELL, 2011)
Protein kinase C beta II (PKC beta II) levels increase in the myocardium of patients with end-stage heart failure (HF). Also targeted overexpression of PKC beta II in the myocardium of mice leads to dilated cardiomyopathy ...
GESTIÓN DE PROCESOS DE MEJORA CONTINUA Y SATISFACCIÓN DE LAS NECESIDADES DE LOS CLIENTES DE LA EMPRESA PKC TECHNOLOGY SRL. 2020
(Universidad Peruana de Ciencias e Informática, 2021-12-04)
La presente investigación se elabora para contextualizar la empresa PKC Technology S.R.L, el problema planteado para el estudio es ¿De qué manera la gestión de procesos de mejora continua permitirá satisfacer las necesidades ...
Protein quality control disruption by PKC beta II in heart failure: rescue by the selective PKC beta II inhibitor, beta IIV5-3
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
Myocardial remodeling and heart failure (HF) are common sequelae of many forms of cardiovascular disease and a leading cause of mortality worldwide. Accumulation of damaged cardiac proteins in heart failure has been ...