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PI3K/AKT pathway is altered in the endometriosis patient’s endometrium and presents differences according to severity stage
(Informa Healthcare, 2019-10)
Based on the inflammatory nature and hormone-dependency of endometriosis, PI3K/AKT signaling appears to influence its progression. Could the endometriosis stages be linked to differential changes in PI3K/AKT pathway ...
Estudo funcional da via PI3K/AKT em Aedes aegypti
(Universidade Estadual Paulista (Unesp), 2018-07-23)
Aedes aegypti é a espécie de mosquito emergente em áreas urbanas com maior impacto na saúde pública, sendo o principal vetor dos arbovírus dengue, Zika e chikungunya. Por esse motivo, se faz indispensável a compreensão de ...
Inhibition of the PI3K/Akt pathway by Ly294002 does not prevent establishment of persistent Junín virus infection in Vero cells
(Springer Wien, 2014-12)
In previous work, we demonstrated that the arenavirus Junín virus (JUNV) is able to activate Akt by means of the phosphatidylinositol-3-kinase (PI3K) survival pathway during virus entry. This work extends our study, ...
Iron-Induced Oxidative Injury Differentially Regulates PI3K/Akt/GSK3β Pathway in Synaptic Endings from Adult and Aged Rats
(Oxford University Press, 2009-10)
In this work we study the state of phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK3 beta) signaling during oxidative injury triggered by free iron using cerebral cortex synaptic endings isolated ...
PI3K/Akt inhibition modulates multidrug resistance and activates NF-κB in murine lymphoma cell lines
(Elsevier, 2008-07)
Upregulation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway has been described in some tumors related to multidrug resistance (MDR). The aim of this work was to analyze the relationship between PI3K/Akt, MDR and ...
Extracellular ATP regulates FoxO family of transcription factors and cell cycle progression through PI3K/Akt in MCF-77 cells
(Elsevier, 2013-09)
Background: Forkhead Box-O (FoxO) transcription factors regulate the expression of many genes involved in suppression. Released nucleotides can regulate intracellular signaling pathways through membrane-bound purinergic ...
Study of PI3K/AKT/mTOR pathway in breast cancer progression
(Instituto de Histología y Embriología, 2018)
Deregulation in the PI3K/AKT/mTOR pathway is associated with breast cancer development. Using experimental models of breast carcinogenesis induced in mice, xenografts of tumor cell lines, and tumors from patients we found ...