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A thermodynamic analysis of the binding specificity between four human pdz domains and eight host, viral and designed ligands
(MDPI AG, 2021-08)
PDZ domains are binding modules mostly involved in cell signaling and cell–cell junctions. These domains are able to recognize a wide variety of natural targets and, among the PDZ partners, viruses have been discovered to ...
PYK2/PDZ-RhoGEF Links Ca(2+) Signaling to RhoA
(LIPPINCOTT WILLIAMS & WILKINS, 2009)
Objective-Ras homolog gene family member A (RhoA)/Rho-kinase-mediated Ca(2+) sensitization is a critical component of constrictor responses. The present study investigates how angiotensin II activates RhoA. Methods and ...
The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane
(Federation of American Societies for Experimental Biology, 2021-07)
The sodium/iodide symporter (NIS) expresses at the basolateral plasma membrane of the thyroid follicular cell and mediates iodide accumulation required for normal thyroid hormonogenesis. Loss-of-function NIS variants cause ...
Normal Hepatic Cell Surface Localization of the High Density Lipoprotein Receptor, Scavenger Receptor Class B, Type I, Depends on All Four PDZ Domains of PDZK1
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2009)
PDZK1 is a four PDZ domain-containing scaffold protein that binds to scavenger receptor class B, type I (SR-BI), the high density lipoprotein receptor, by its first PDZ domain (PDZ1). PDZK1 knock-out mice exhibit a >95% ...
Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localization
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2008)
PDZK1 is a four-PDZ domain-containing scaffold protein that, via its first PDZ domain (PDZ1), binds to the C terminus of the high density lipoprotein (HDL) receptor scavenger receptor, class B, type I (SR-BI). Abolishing ...
Identification of PDZ5, a candidate universal minicircle sequence binding protein of Trypanosoma cruzi
(Elsevier B.V., 2003-07-30)
The dodecamer universal minicircle sequence is a conserved sequence present in minicircles of trypanosomatid kinetoplast DNA studied so far. This sequence is recognised by a protein named universal minicircle sequence ...
Pdz-containing proteins: alternative splicing as a source of functional diversity
(ELSEVIER SCIENCE BV, 2004)
Overexpression of the pdz1 domain of pdzk1 blocks the activity of hepatic scavenger receptor, class b, type i by altering its abundance and cellular localization
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2008)