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Alpha7 Nicotinic Acetylcholine Receptor Expression and Activity During Neuronal Differentiation of PC12 Pheochromocytoma Cells
(HUMANA PRESS INC, 2010)
Nicotinic acetylcholine receptors (nAChR) exert pivotal roles in synaptic transmission, neuroprotection and differentiation. Particularly, homomeric alpha 7 receptors participate in neurite outgrowth, presynaptic control ...
Tl(I) and Tl(III) alter the expression of EGF-dependent signals and cyclins required for pheochromocytoma (PC12) cell-cycle resumption and progression
(Wiley, 2015-08)
The effects of thallium [Tl(I) and Tl(III)] on the PC12 cell cycle were evaluated without (EGF−) or with (EGF+) media supplementation with epidermal growth factor (EGF). The following markers of cell-cycle phases were ...
A novel physiological property of snake bradykinin-potentiating peptides-Reversion of MK-801 inhibition of nicotinic acetylcholine receptors
(ELSEVIER SCIENCE INC, 2008)
The first naturally occurring angiotensin-converting enzyme (ACE) inhibitors described are pyroglutamyl proline-rich oligopeptides, found in the venom of the viper Bothrops jararaca, and named as bradykinin-potentiating ...
Impact of Reck expression and promoter activity in neuronal in vitro differentiation
(Springer, 2021-02-22)
Reck (REversion-inducing Cysteine-rich protein with Kazal motifs) tumor suppressor gene encodes a multifunctional glycoprotein which inhibits the activity of several matrix metalloproteinases (MMPs), and has the ability ...
Epidermal growth factor prevents thallium(I)- and thallium(III)-mediated rat pheochromocytoma (PC12) cell apoptosis
(Springer, 2017-03)
We have reported recently that the proliferation of PC12 cells exposed to micromolar concentrations of Tl(I) or Tl(III) has different outcomes, depending on the absence (EGF− cells) or the presence (EGF+ cells) of epidermal ...
Endosomes and lysosomes are involved in early steps of Tl(III)-mediated apoptosis in rat pheochromocytoma (PC12) cells
(Springer, 2012-11)
The mechanisms that mediate thallium (Tl) toxicity are still not completely understood. The exposure of rat pheochromocytoma (PC12) cells to Tl(I) or Tl(III) activates both mitochondrial (Tl(I) and Tl(III)) and extrinsic ...
Early response of glutathione- and thioredoxin-dependent antioxidant defense systems to Tl(I)- and Tl(III)-mediated oxidative stress in adherent pheochromocytoma (PC12adh) cells
(Springer, 2017-09)
Thallium (Tl) is a toxic heavy metal that causes oxidative stress both in vitro and in vivo. In this work, we evaluated the production of oxygen (ROS)- and nitrogen (RNS)-reactive species in adherent PC12 (PC12adh) cells ...
Envolvimento da proteína neuronal sensora de cálcio-1 (NCS-1) na sinalização muscarínica em células PC12
(Universidade Federal de Minas GeraisUFMG, 2007-06-19)
Neuronal calcium sensor-1 (NCS-1) belongs to the superfamily of EF-hand Ca2+ binding protein. Overexpression of NCS-1 was implicated on potentiation of synaptic transmission and plasticity in many experimental models. In ...
Damaging effects of BMAA on retina neurons and Müller glial cells
(Elsevier Science Ltd, 2020-11-01)
B–N-methylamino-L-alanine (BMAA), a cyanotoxin produced by most cyanobacteria, has been proposed to cause long term damages leading to neurodegenerative diseases, including Amyotrophic Lateral Sclerosis/Parkinsonism Dementia ...