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Role of TcPARP during the metacyclogenesis of Trypanosoma cruzi
(The Australian Society for Parasitology, 2020)
Poly(ADP-ribosyl)ation is a post-translational modification catalyzed by poly(ADP- ribose)polymerases (PARPs). As a reversible modification, it is regulated by a delicate balance ofsynthesis and degradation, and is involved ...
Efeitos do treinamento resistido e da reposição de 17beta-estradiol em ratas ovariectomizadas na modulação de p-AKT e PARP-1 clivada no hipocampo
(Universidade Federal de São CarlosUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCFCâmpus São Carlos, 2016-09-08)
Menopause is a physiological process associated with physiological changes that lead to
increased incidence of some diseases such as sarcopenia, cardiovascular disease, diabetes
mellitus and neurodegenerative diseases. ...
Structural and Biochemical Characterization of Poly-ADP-ribose Polymerase from Trypanosoma brucei
(Nature Publishing Group, 2017-06)
Trypanosoma brucei is a unicellular parasite responsible for African trypanosomiasis or sleeping sickness.It contains a single PARP enzyme opposed to many higher eukaryotes, which have numerous PARPs.PARPs are responsible ...
Metabolism of Poly-ADP-ribose in Trypanosomatids
(Nova Science Publishers, Inc, 2010)
The poly-ADP-ribosylation reaction is a post-translational modification involved invarious cellular processes including DNA repair, DNA replication, gene expression,maintenance of genomic stability, cell death and cellular ...
TcPARP: A DNA damage-dependent poly(ADP-ribose) polymerase from Trypanosoma cruzi
(Elsevier, 2008-03)
Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme present in most eukaryotes and has been involved in processes such as DNA repair and gene expression. The poly(ADP-ribose) polymer (PAR) is mainly catabolised by ...
Expression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV)
(SPRINGERDORDRECHT, 2012)
Cervical cancer remains persistently the second most common malignancies among women worldwide, responsible for 500,000 new cases annually. Only in Brazil, the estimate is for 18,430 new cases in 2011. Several types of ...
Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei
(BioMed Central, 2016-03)
Poly(ADP-ribose) (PAR) metabolism participates in several biological processes such as DNA damage signaling and repair, which is a thoroughly studied function. PAR is synthesized by Poly(ADP-ribose) polymerase (PARP) and ...
Istmo Centroamericano: programa de actividades regionales en planificación eléctrica (PARPE)
(CEPAL, Sede Subregional en México, 1992-10-09)
Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors
(Springer, 2019-02-01)
Due to their unique and versatile biochemical properties, ruthenium-based compounds have emerged as promising anticancer agents. Previous studies showed that three ruthenium(II) compounds: [Ru(pySH)(bipy)(dppb)]PF6 (1), ...
Estudo da relação entre PARP-1 e adiponectina em pessoas com lipodistrofia generalizada congênita tipo 2
(Universidade Federal do Rio Grande do NorteBrasilUFRNBiomedicinaCentro de Biociências, 2023)