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A low concentration of ouabain (0.18 µg/kg) enhances hypertension in spontaneously hypertensive rats by inhibiting the Na+ pump and activating the renin-angiotensin system
(2010-08)
We investigated the effects of low ouabain concentrations on systolic (SAP) and diastolic (DAP) arterial pressures and on pressor reactivity in 3-month-old male spontaneously hypertensive rats (SHR). Arterial blood pressure ...
Effects of small doses of ouabain on the arterial blood pressure of anesthetized hypertensive and normotensive rats
(2001-08)
Ouabain increases vascular resistance and may induce hypertension by inhibiting the Na+ pump. The effects of 0.18 and 18 µg/kg, and 1.8 mg/kg ouabain pretreatment on the phenylephrine (PHE; 0.1, 0.25 and 0.5 µg, in ...
Is ouabain produced by the adrenal gland?
(1998)
Ouabain or a related stereoisomer, termed endogenous ouabain, has been identified in adrenal cortex tissue and culture medium from adrenocortical cells.Angiotensin II and adrenocorticotropin, the main activators of aldosterone ...
Effects of ouabain on vascular reactivity
(1997-04)
Ouabain is an endogenous substance occurring in the plasma in the nanomolar range, that has been proposed to increase vascular resistance and induce hypertension. This substance acts on the a-subunit of Na+,K+-ATPase ...
Chronic ouabain treatment exacerbates blood pressure elevation in spontaneously hypertensive rats: the role of vascular mechanisms
(LIPPINCOTT WILLIAMS & WILKINS, 2009)
Objective Hypertensive rats are more sensitive to the pressor effects of acute ouabain than normotensive rats. We analyzed the effect of chronic ouabain (similar to 8.0 mu g/day, 5 weeks) treatment on the blood pressure ...
Ouabain-sensitive Na+, K+-ATPase in the plasma membrane of Leishmania mexicana
(Molecular and biochemical parasitology, 2017)
Long-Term Ouabain Treatment Impairs Vascular Function in Resistance Arteries
(KARGER, 2011)
Background/Aims: The purpose of this study was to examine the cardiovascular effects of long-term ouabain treatment at different time points. Methods: Systolic blood pressure (SBP) was measured by tail-cuff method in male ...
Time-dependent increases in ouabain-sensitive Na(+), K(+)-ATPase activity in aortas from diabetic rats: The role of prostanoids and protein kinase C
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
Aims: Na(+), K(+)-ATPase activity contributes to the regulation of vascular contractility and it has been suggested that vascular Na(+), K(+)-ATPase activity may be altered during the progression of diabetes; however the ...
Rapid eye movement sleep deprivation induces changes in the high-affinity binding of [H-3]-ouabain to the rat cortical membranes
(Elsevier B.V., 2006-03-27)
Rapid eye movement sleep (REMS) suppresses seizures. On the other hand, REMS deprivation (REMSD) increases brain susceptibility to seizures. Sodium-postassium/ATPase is involved in the control of brain excitability. Ouabain, ...