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Role of the nuclear factor kappa Beta ligand (RANKL) in osteoarthritis and oseteoclastogenesis in thoroughbred horses. Use of anti-inflammatory drugs.Rol del ligando del factor nuclear kappa Beta (RANKL) en osteoartritis y osteoclastogénesis de equinos fina sangre de carrera. Uso de antiinflamatorios
(Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria, 2021)
Brucella abortus-infected macrophages modulate T lymphocytes to promote osteoclastogenesis via IL-17
(American Society of Investigative Pathology, 2012-09)
The pathogenic mechanisms of bone loss caused by Brucella species have not been completely deciphered. Although T lymphocytes (LTs) are considered important to control infection, the mechanism of Brucella-induced T-cell ...
Gaucher disease-associated alterations in mesenchymal stem cells reduce osteogenesis and favour adipogenesis processes with concomitant increased osteoclastogenesis
(Academic Press Inc Elsevier Science, 2020-08)
Gaucher disease (GD) is caused by pathogenic mutations in GBA1, the gene that encodes the lysosomal enzyme β-glucocerebrosidase. Until now, treatments for GD cannot completely reverse bone problems. The aim of this work ...
Oral squamous carcinoma cells secrete RANKL directly supporting osteolytic bone loss
(Elsevier B.V., 2013-02-01)
Objective: Local invasion of bone is a frequent complication of oral squamous cell carcinoma (OSCC). Development of these osteolytic lesions is mediated by osteoclasts. Receptor activation of NF-kappa B ligand (RANKL) ...
Magnesium deficiency results in an increased formation of osteoclasts
(2013-03-19)
Magnesium (Mg2+) deficiency is a frequently occurring disorder that leads to loss of bone mass, abnormal bone growth and skeletal weakness. It is not clear whether Mg2+ deficiency affects the formation and/or activity of ...
Jaw and Long Bone Marrows Have a Different Osteoclastogenic Potential
(Springer, 2011-01-01)
Osteoclasts, the multinucleated bone-resorbing cells, arise through fusion of precursors from the myeloid lineage. However, not all osteoclasts are alike; osteoclasts at different bone sites appear to differ in numerous ...
Magnesium deficiency results in an increased formation of osteoclasts
(2013-03-19)
Magnesium (Mg2+) deficiency is a frequently occurring disorder that leads to loss of bone mass, abnormal bone growth and skeletal weakness. It is not clear whether Mg2+ deficiency affects the formation and/or activity of ...
Staphylococcus aureus protein A enhances osteoclastogenesis via TNFR1 and EGFR signaling
(Elsevier Science, 2016-10)
Staphylococcus aureus is a major causative agent of osteomyelitis in adults and children. The increasing incidence of antimicrobial resistant isolates and the morbidity of this type of infection denote that alternative ...
Receptor activator NF kappa B-ligand and osteoprotegerin protein expression in human periapical cysts and granulomas
(Mosby, IncSt LouisEUA, 2006)
A dominant function of p38 mitogen-activated protein kinase signaling in receptor activator of nuclear factor-kappa B ligand expression and osteoclastogenesis induction by Aggregatibacter actinomycetemcomitans and Escherichia coli lipopolysaccharide
(Blackwell Publishing, 2008-04-01)
Background and Objective: Lipopolysaccharide from gram-negative bacteria is one of the microbial-associated molecular patterns that initiate the immune/inflammatory response, leading to the tissue destruction observed in ...