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Fibroblast contributes for osteoblastic phenotype in a MAPK-ERK and sonic hedgehog signaling-independent manner
(2017-12-01)
We hypothesized that a crosstalk between osteoblast and fibroblast (FB) exists, which contributes to bone as a dynamic tissue. Cell-free supernatants were harvested from fibroblast cultures and later subject pre-osteoblasts ...
Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts
(Wiley-Liss Inc., 2018)
© 2018 Wiley Periodicals, Inc. Expression of Runx2/p57 is a hallmark of the osteoblast-lineage identity. Although several regulators that control the expression of Runx2/p57 during osteoblast-lineage commitment have been ...
Osteoblast differentiation is enhanced by a nano-to-micro hybrid titanium surface created by Yb:YAG laser irradiation
(Springer, 2015-07-30)
The aim of this study was to analyze the capacity of a new modified laser surface to stimulate calvarial osteoblasts isolated from neonatal mouse bones to differentiate and form mineralized nodules. Titanium discs were ...
Osteoblasts engulf apoptotic bodies during alveolar bone formation in the rat maxilla
(Wiley-Blackwell, 2005-09-01)
During bone formation, as in other tissues and organs, intense cellular proliferation and differentiation are usually observed. It has been described that programmed cell death, i.e., apoptosis, takes place in the control ...
Zoledronic Acid Inhibits Human Osteoblast Activities
(Karger, 2013-01-01)
Background: Bisphosphonates are potent inhibitors of bone resorption. These kinds of drugs, which are used for the treatment of osteolytic diseases, have been associated with the occurrence of oral osteonecrosis, especially ...
The importance of estrogen for bone protection in experimental hyperthyroidism in human osteoblasts
(2019-08-15)
Triiodothyronine (T3) and estrogen (E2) play important roles in the bone remodeling process and signaling of receptor activator of the nuclear factor-kappa β (RANKL) and osteoprotegerin (OPG) expressed by osteoblasts. ...
HOXA cluster gene expression during osteoblast differentiation involves epigenetic control
(2019-08-01)
The HOXA gene cluster is generally recognized as a pivotal mediator of positional identity in the skeletal system, expression of different orthologues conferring alternative locational phenotype of the vertebrate bone. ...
Influence of bisphosphonates on the behavior of osteoblasts seeded onto titanium discs
(2020-05-01)
Among other factors, types of bisphosphonates and treatment regimens seem to be strongly associated with the success or failure of installation of osseointegrated implants. This study investigated the influence of two ...
Low-level laser therapy for osteonecrotic lesions: effects on osteoblasts treated with zoledronic acid
(Springer, 2014-10-01)
Clinical studies have shown that low-level laser therapy (LLLT) can improve local tissue healing of bisphosphonate-induced osteonecrosis of the jaw. However, the effects of laser irradiation on bisphosphonate-treated ...
High doses of alcohol during pregnancy cause DNA damages in osteoblasts of newborns rats
(2016-02-01)
Background: Alcohol exerts teratogenic effects and its consumption during pregnancy can cause deficit of bone development. The aim of the current study was to evaluate the genotoxic effects of prenatal exposure to ethanol ...