Search
Now showing items 1-10 of 29
WNT16 is robustly increased by oncostatin m in mouse calvarial osteoblasts and acts as a negative feedback regulator of osteoclast formation induced by oncostatin M
(2021-01-01)
Background: Bone loss is often observed adjacent to inflammatory processes. The WNT signaling pathways have been implicated as novel regulators of both immune responses and bone metabolism. WNT16 is important for cortical ...
Oncostatina M controla a diferenciação de osteoblastos através do eixo OSMR-Shc1-STAT3: um novo caminho para a formação óssea
(Universidade Estadual Paulista (Unesp), 2021-09-22)
Processos inflamatórios próximos ao tecido ósseo levam, clinicamente, à reabsorção desse tecido. Porém, a noção corrente de que a inflamação inibe a formação de osso vem sendo questionada por estudos que comprovam o papel ...
Activation of Shc1 allows oncostatin M to induce RANKL and osteoclast formation more effectively than leukemia inhibitory factor
(2019-01-01)
Background and Purpose: The gp130 family of cytokines signals through receptors dimerizing with the gp130 subunit. Downstream signaling typically activates STAT3 but also SHP2/Ras/MAPK pathways. Oncostatin M (OSM) is a ...
Oncostatin M is a novel glucocorticoid-dependent neuroinflammatory factor that enhances oligodendrocyte precursor cell activity in demyelinated sites
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010)
The innate immune reaction to tissue injury is a natural process, which can have detrimental effects in the absence of negative feedbacks by glucocorticoids (GCs). Although acute lipopolysaccharide (LPS) challenge is ...
The role of cytokines in inflammatory bone loss
(2013-09-12)
Chronic inflammatory processes close to bone often lead to loss of bone in diseases such as rheumatoid arthritis, periodontitis, loosened joint prosthesis and tooth implants. This is mainly due to local formation of bone ...
The role of cytokines in inflammatory bone loss
(2013-09-12)
Chronic inflammatory processes close to bone often lead to loss of bone in diseases such as rheumatoid arthritis, periodontitis, loosened joint prosthesis and tooth implants. This is mainly due to local formation of bone ...
The effects of immunomodulation by macrophage subsets on osteogenesis in vitro
(BioMed Central, 2016)
Background: Bone formation and remodeling are influenced by the inflammatory state of the local microenvironment. In this regard, macrophages are postulated to play a crucial role in modulating osteogenesis. However, the ...
Stimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2
(Sage Publications Inc, 2010-08-01)
The osteotropic interleukin-6 (IL-6) types of cytokines IL-6, IL-11, and leukemia inhibitory factor (LIF), but not oncostatin M, are expressed by human gingival fibroblasts, and their expressions are regulated by IL-1 and ...