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Leishmania replication protein A-1 binds in vivo single-stranded telomeric DNA
(Elsevier B.V., 2007-06-29)
Replication protein A (RPA) is a highly conserved heterotrimeric single-stranded DNA-binding protein involved in different events of DNA metabolism. In yeast, subunits 1 (RPA-1) and 2 (RPA-2) work also as telomerase ...
Leishmania replication protein A-1 binds in vivo single-stranded telomeric DNA
(Elsevier B.V., 2007-06-29)
Replication protein A (RPA) is a highly conserved heterotrimeric single-stranded DNA-binding protein involved in different events of DNA metabolism. In yeast, subunits 1 (RPA-1) and 2 (RPA-2) work also as telomerase ...
RPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain
(Elsevier B.V., 2014-12-20)
Replication protein A-1 (RPA-1) is a single-stranded DNA-binding protein involved in DNA metabolism. We previously demonstrated the interaction between LaRPA-1 and telomeric DNA. Here, we expressed and purified truncated ...
RPA-1 from Leishmania sp.: Recombinant Protein Expression and Purification, Molecular Modeling, and Molecular Dynamics Simulations Protocols
(2021-01-01)
RPA is a conserved heterotrimeric complex and the major single-stranded DNA (ssDNA)-binding protein heterotrimeric complex, which in eukaryotes is formed by the RPA-1, RPA-2, and RPA-3 subunits. The main structural feature ...
A multi-approach analysis highlights the relevance of RPA-1 as a telomere end-binding protein (TEBP) in Leishmania amazonensis
(2020-07-01)
Background: Telomeres are chromosome end structures important in the maintenance of genome homeostasis. They are replenished by the action of telomerase and associated proteins, such as the OB (oligonucleotide/oligosacch ...
Bradykinin inhibits hepatic gluconeogenesis in obese mice
(Nature Publishing Group, 2012-10-01)
The kallikrein-kinin system (KKS) has been previously linked to glucose homeostasis. in isolated muscle or fat cells, acute bradykinin (BK) stimulation was shown to improve insulin action and increase glucose uptake by ...
Allergen-Induced Bone Marrow Eosinophilopoiesis and Airways Eosinophilic Inflammation in Leptin-Deficient ob/ob Mice
(Nature Publishing GroupNew YorkEUA, 2012)
Leishmania replication protein A-1 binds in vivo single-stranded telomeric DNA
(Elsevier B.V., 2014)